BACKGROUND The effectiveness of eculizumab (terminal complement inhibitor) at the acetylcholine receptor (AChR) antibody-negative general myasthenia gravis (GMG) is unknown. CASE REPORT A female patient was diagnosed with AChR-antibody and muscle-specific kinase (musk) antibody-negative GMG in March 2016. In January 2017, the patient was referred for plasma exchange (PLEX) because the symptoms continue.
He also received azathioprine, mycophenolate mofetil, and pyridostigmine (all continued during subsequent therapy). PLEX (5 sessions for 10 days) was initially effective, but over the next month PLEX patients received weekly, then twice a week, followed by 3 times a week for symptoms to worsen. In April 2018, PLEX reduced to two times a week following initiation of eculizumab (weekly induction dose of 900 mg 1 day after the first PLEX, plus 600 mg on day PLEX second session, for 4 weeks).
Patients then stabilized eculizumab 1200 mg every 2 weeks and PLEX treatment frequency reduced, until PLEX stopped on Sunday 39 after initiation of eculizumab. During eculizumab treatment, myasthenia gravis patients with activities of daily living (MG-ADL) scores decreased 9-1 or second most votes, with a temporary increase to 4 or 5 between Weeks 19 and 27 after eculizumab treatment less often. No side effects related to eculizumab.
CONCLUSION After the transition from three times a week PLEX for eculizumab in patients with treatment-refractory, AChR antibodies and antibody-negative musk GMG, there is clinically significant improvement in daily activities are affected by the symptoms of MG. Further investigation of eculizumab in antibody-negative MG necessary.
Human Tubulin Beta 3 (TUBb3) ELISA Kit |
RDR-TUBb3-Hu-48Tests |
Reddot Biotech |
48 Tests |
EUR 544 |
Human Tubulin Beta 3 (TUBb3) ELISA Kit |
RDR-TUBb3-Hu-96Tests |
Reddot Biotech |
96 Tests |
EUR 756 |
TUBB3 Antibody |
CSB-PA969690- |
Cusabio |
|
EUR 335 |
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100 |
TUBB3 Antibody |
CSB-PA969690-100ul |
Cusabio |
100ul |
EUR 316 |
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100 |
TUBB3 Antibody |
CSB-PA884597- |
Cusabio |
|
EUR 335 |
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
TUBB3 Antibody |
CSB-PA884597-100ul |
Cusabio |
100ul |
EUR 316 |
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000 |
TUBB3 Antibody |
1-CSB-PA004349 |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000 |
TUBB3 Antibody |
1-CSB-PA000385 |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB;WB:1:2000-5000 |
TUBB3 Antibody |
1-CSB-PA000393 |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB;WB:1:2000-5000 |
TUBB3 Antibody |
1-CSB-PA03874A0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
TUBB3 Antibody |
1-CSB-PA03879A0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
TUBB3 Antibody |
1-CSB-PA025323GA01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
TUBB3 Antibody |
1-CSB-PA917452 |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:500-1:5000, WB:1:500-1:1000, IHC:1:25-1:50 |
TUBB3 Antibody |
35539-100ul |
SAB |
100ul |
EUR 252 |
TUBB3 siRNA |
20-abx938564 |
Abbexa |
|
|
|
TUBB3 siRNA |
20-abx938565 |
Abbexa |
|
|
|
TUBB3 siRNA |
20-abx905870 |
Abbexa |
|
|
|
TUBB3 Antibody |
AF7000 |
Affbiotech |
200ul |
EUR 304 |
Description: TUBB3 Antibody detects endogenous levels of total TUBB3. |
TUBB3 Antibody |
BF0572 |
Affbiotech |
200ul |
EUR 376 |
Description: TUBB3 antibody detects endogenous levels of total TUBB3. |
TUBB3 antibody |
10R-10559 |
Fitzgerald |
100 ug |
EUR 349 |
Description: Mouse monoclonal TUBB3 antibody |
TUBB3 antibody |
10R-6182 |
Fitzgerald |
100 ul |
EUR 726 |
Description: Mouse monoclonal TUBB3 antibody |
TUBB3 antibody |
10R-8390 |
Fitzgerald |
100 ul |
EUR 392 |
Description: Mouse monoclonal TUBB3 antibody |
TUBB3 antibody |
10R-1824 |
Fitzgerald |
100 ul |
EUR 403 |
Description: Mouse monoclonal TUBB3 antibody |
TUBB3 Peptide |
43-094P |
ProSci |
0.1 mg |
EUR 338 |
Description: TUBB3 Peptide |
TUBB3 antibody |
70R-21061 |
Fitzgerald |
50 ul |
EUR 435 |
Description: Rabbit polyclonal TUBB3 antibody |
TUBB3 antibody |
70R-15421 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal TUBB3 antibody |
TUBB3 cloning plasmid |
CSB-CL623813HU-10ug |
Cusabio |
10ug |
EUR 233 |
|
Description: A cloning plasmid for the TUBB3 gene. |
Anti-TUBB3 antibody |
STJ11100102 |
St John's Laboratory |
100 µl |
EUR 393 |
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. |
Anti-TUBB3 antibody |
STJ113476 |
St John's Laboratory |
50 µl |
EUR 287 |
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. |
TUBB3 Monoclonal Antibody |
30323-100ul |
SAB |
100ul |
EUR 252 |
TUBB3 Monoclonal Antibody |
30323-50ul |
SAB |
50ul |
EUR 187 |
TUBB3 Polyclonal Antibody |
A51998 |
EpiGentek |
100 µg |
EUR 570.55 |
Description: kits suitable for this type of research |
TUBB3 Polyclonal Antibody |
A53965 |
EpiGentek |
100 µg |
EUR 570.55 |
Description: Ask the seller for details |
TUBB3 Mouse mAb |
A18132-100ul |
Abclonal |
100 ul |
EUR 384 |
TUBB3 Mouse mAb |
A18132-20ul |
Abclonal |
20 ul |
EUR 183 |
TUBB3 Mouse mAb |
A18132-50ul |
Abclonal |
50 ul |
EUR 265 |
TUBB3 Mouse mAb |
A18132-200ul |
Abclonal |
200 ul |
EUR 554 |
TUBB3 Rabbit pAb |
A17073-100ul |
Abclonal |
100 ul |
EUR 308 |
TUBB3 Rabbit pAb |
A17073-200ul |
Abclonal |
200 ul |
EUR 459 |
TUBB3 Rabbit pAb |
A17073-20ul |
Abclonal |
20 ul |
EUR 183 |
TUBB3 Rabbit pAb |
A17073-50ul |
Abclonal |
50 ul |
EUR 223 |
TUBB3 Rabbit pAb |
A17074-100ul |
Abclonal |
100 ul |
EUR 308 |
TUBB3 Rabbit pAb |
A17074-200ul |
Abclonal |
200 ul |
EUR 459 |
TUBB3 Rabbit pAb |
A17074-20ul |
Abclonal |
20 ul |
EUR 183 |
TUBB3 Rabbit pAb |
A17074-50ul |
Abclonal |
50 ul |
EUR 223 |
TUBB3 Conjugated Antibody |
C35539 |
SAB |
100ul |
EUR 397 |
TUBB3 Blocking Peptide |
AF7000-BP |
Affbiotech |
1mg |
EUR 195 |
TUBB3 Blocking Peptide |
BF0572-BP |
Affbiotech |
1mg |
EUR 195 |
anti-TUBB3 (2E9) |
LF-MA30351 |
Abfrontier |
100 ul |
EUR 486 |
Description: Mouse Monoclonal to TUBB3 |
TUBB3 antibody (HRP) |
60R-2074 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal TUBB3 antibody (HRP) |
TUBB3 antibody (FITC) |
60R-2075 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal TUBB3 antibody (FITC) |
TUBB3 antibody (biotin) |
60R-2076 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal TUBB3 antibody (biotin) |
TUBB3 Antibody, HRP conjugated |
1-CSB-PA03874B0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
TUBB3 Antibody, FITC conjugated |
1-CSB-PA03874C0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
TUBB3 Antibody, Biotin conjugated |
1-CSB-PA03874D0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
TUBB3 Antibody, HRP conjugated |
1-CSB-PA03879B0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
TUBB3 Antibody, FITC conjugated |
1-CSB-PA03879C0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
TUBB3 Antibody, Biotin conjugated |
1-CSB-PA03879D0Rb |
Cusabio |
|
|
|
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Rat TUBB3 shRNA Plasmid |
20-abx987934 |
Abbexa |
|
|
|
Mouse TUBB3 shRNA Plasmid |
20-abx973259 |
Abbexa |
|
|
|
Human TUBB3 shRNA Plasmid |
20-abx957032 |
Abbexa |
|
|
|
TUBB3 Monoclonal Conjugated Antibody |
C30323 |
SAB |
100ul |
EUR 397 |
anti- TUBB3 specific antibody |
FNab09890 |
FN Test |
100µg |
EUR 548.75 |
|
Description: Antibody raised against TUBB3 specific |
TUBB3 Recombinant Protein (Human) |
RP033454 |
ABM |
100 ug |
Ask for price |
TUBB3 Recombinant Protein (Mouse) |
RP182243 |
ABM |
100 ug |
Ask for price |
TUBB3 Recombinant Protein (Rat) |
RP235280 |
ABM |
100 ug |
Ask for price |
TUBB3 protein (His tag) |
80R-2700 |
Fitzgerald |
50 ug |
EUR 424 |
Description: Purified recombinant TUBB3 protein (His tag) |
Recombinant Tubulin Beta 3 (TUBb3) |
4-RPE711Hu01 |
Cloud-Clone |
-
EUR 512.16
-
EUR 240.00
-
EUR 1645.60
-
EUR 615.20
-
EUR 1130.40
-
EUR 406.00
-
EUR 3964.00
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Human Tubulin Beta 3 expressed in: E.coli |
Polyclonal TUBB3 Antibody (N-term) |
AMM05459G |
Leading Biology |
0.1ml |
EUR 484 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TUBB3 (N-term). This antibody is tested and proven to work in the following applications: |
Monoclonal TUBB3 Antibody, Clone: 2E9 |
APR13880G |
Leading Biology |
0.1ml |
EUR 484 |
Description: A Monoclonal antibody against Human TUBB3. The antibodies are raised in Mouse and are from clone 2E9. This antibody is applicable in WB, FC, ICC, E |
Tubulin Beta 3 (TUBB3) Antibody |
abx127119-50ul |
Abbexa |
50 ul |
EUR 411 |
|
Tubulin, Beta 3 (TUBB3) Antibody |
20-abx116351 |
Abbexa |
|
|
|
Tubulin Beta 3 (TUBB3) Antibody |
20-abx121803 |
Abbexa |
-
EUR 300.00
-
EUR 439.00
-
EUR 189.00
|
|
|
Tubulin Beta 3 (TUBB3) Antibody |
20-abx110304 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Tubulin Beta 3 (TUBB3) Antibody |
20-abx110305 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Tubulin Beta 3 (TUBB3) Antibody |
20-abx123449 |
Abbexa |
-
EUR 592.00
-
EUR 857.00
-
EUR 217.00
-
EUR 411.00
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
Tubulin Beta 3 (TUBB3) Antibody |
20-abx002044 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 314.00
|
|
|
Tubulin Beta 3 (TUBB3) Antibody |
20-abx101413 |
Abbexa |
-
EUR 425.00
-
EUR 133.00
-
EUR 1205.00
-
EUR 578.00
-
EUR 328.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Tubulin Beta 3 (TUBB3) Antibody |
abx036052-100ug |
Abbexa |
100 ug |
EUR 391 |
|
beta 3-Tubulin (TUBB3) Antibody |
20-abx134677 |
Abbexa |
-
EUR 356.00
-
EUR 537.00
-
EUR 217.00
|
|
|
Tubulin Beta 3 (TUBB3) Antibody |
20-abx134678 |
Abbexa |
-
EUR 356.00
-
EUR 537.00
-
EUR 217.00
|
|
|
Tubulin Beta 3 (TUBB3) Antibody |
20-abx134679 |
Abbexa |
-
EUR 356.00
-
EUR 537.00
-
EUR 217.00
|
|
|
Tubulin Beta 3 (TUBB3) Antibody |
20-abx134680 |
Abbexa |
-
EUR 356.00
-
EUR 537.00
-
EUR 217.00
|
|
|
Tubulin Beta 3 (TUBB3) Antibody |
20-abx134681 |
Abbexa |
-
EUR 356.00
-
EUR 537.00
-
EUR 217.00
|
|
|
beta 3-Tubulin (TUBB3) Antibody |
20-abx134682 |
Abbexa |
-
EUR 356.00
-
EUR 537.00
-
EUR 217.00
|
|
|
Tubulin Beta 3 (TUBB3) Antibody |
20-abx134683 |
Abbexa |
-
EUR 356.00
-
EUR 537.00
-
EUR 217.00
|
|
|
beta III-Tubulin (TUBB3) Antibody |
abx139401-01mg |
Abbexa |
0.1 mg |
EUR 411 |
|
Tubulin Beta 3 (TUBB3) Antibody |
abx012294-100ul |
Abbexa |
100 ul |
EUR 411 |
|
Tubulin Beta 3 (TUBB3) Antibody |
abx032605-400ul |
Abbexa |
400 ul |
EUR 523 |
|