Successful Transition from Plasma Exchange to Eculizumab in Acetylcholine Receptor Antibody- and Muscle-Specific Kinase (MuSK) Antibody-Negative Myasthenia Gravis: A Case Report.

BACKGROUND The effectiveness of eculizumab (terminal complement inhibitor) at the acetylcholine receptor (AChR) antibody-negative general myasthenia gravis (GMG) is unknown. CASE REPORT A female patient was diagnosed with AChR-antibody and muscle-specific kinase (musk) antibody-negative GMG in March 2016. In January 2017, the patient was referred for plasma exchange (PLEX) because the symptoms continue.

He also received azathioprine, mycophenolate mofetil, and pyridostigmine (all continued during subsequent therapy). PLEX (5 sessions for 10 days) was initially effective, but over the next month PLEX patients received weekly, then twice a week, followed by 3 times a week for symptoms to worsen. In April 2018, PLEX reduced to two times a week following initiation of eculizumab (weekly induction dose of 900 mg 1 day after the first PLEX, plus 600 mg on day PLEX second session, for 4 weeks).

Patients then stabilized eculizumab 1200 mg every 2 weeks and PLEX treatment frequency reduced, until PLEX stopped on Sunday 39 after initiation of eculizumab. During eculizumab treatment, myasthenia gravis patients with activities of daily living (MG-ADL) scores decreased 9-1 or second most votes, with a temporary increase to 4 or 5 between Weeks 19 and 27 after eculizumab treatment less often. No side effects related to eculizumab.

CONCLUSION After the transition from three times a week PLEX for eculizumab in patients with treatment-refractory, AChR antibodies and antibody-negative musk GMG, there is clinically significant improvement in daily activities are affected by the symptoms of MG. Further investigation of eculizumab in antibody-negative MG necessary.

Human Tubulin Beta 3 (TUBb3) ELISA Kit
RDR-TUBb3-Hu-48Tests 48 Tests
EUR 544

Human Tubulin Beta 3 (TUBb3) ELISA Kit
RDR-TUBb3-Hu-96Tests 96 Tests
EUR 756

Tubb3/ Rat Tubb3 ELISA Kit
ELI-05371r 96 Tests
EUR 657

TUBB3 Antibody
CSB-PA969690-
EUR 335
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

TUBB3 Antibody
CSB-PA969690-100ul 100ul
EUR 316
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

TUBB3 Antibody
CSB-PA884597-
EUR 335
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

TUBB3 Antibody
CSB-PA884597-100ul 100ul
EUR 316
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

TUBB3 Antibody
1-CSB-PA004349
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000

TUBB3 Antibody
1-CSB-PA000385
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB;WB:1:2000-5000

TUBB3 Antibody
1-CSB-PA000393
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB;WB:1:2000-5000

TUBB3 Antibody
1-CSB-PA03874A0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

TUBB3 Antibody
1-CSB-PA03879A0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200

TUBB3 Antibody
1-CSB-PA025323GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

TUBB3 Antibody
1-CSB-PA917452
  • EUR 317.00
  • EUR 244.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:500-1:5000, WB:1:500-1:1000, IHC:1:25-1:50

TUBB3 Antibody
35539-100ul 100ul
EUR 252

TUBB3 siRNA
20-abx938564
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

TUBB3 siRNA
20-abx938565
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

TUBB3 siRNA
20-abx905870
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

TUBB3 Antibody
AF7000 200ul
EUR 304
Description: TUBB3 Antibody detects endogenous levels of total TUBB3.

TUBB3 Antibody
BF0572 200ul
EUR 376
Description: TUBB3 antibody detects endogenous levels of total TUBB3.

pOTB7-TUBB3
PVT18504 2 ug
EUR 231

TUBB3 antibody
10R-10559 100 ug
EUR 349
Description: Mouse monoclonal TUBB3 antibody

TUBB3 antibody
10R-6182 100 ul
EUR 726
Description: Mouse monoclonal TUBB3 antibody

TUBB3 antibody
10R-8390 100 ul
EUR 392
Description: Mouse monoclonal TUBB3 antibody

TUBB3 antibody
10R-1824 100 ul
EUR 403
Description: Mouse monoclonal TUBB3 antibody

TUBB3 Peptide
43-094P 0.1 mg
EUR 338
Description: TUBB3 Peptide

TUBB3 antibody
70R-21061 50 ul
EUR 435
Description: Rabbit polyclonal TUBB3 antibody

TUBB3 antibody
70R-15421 100 ug
EUR 327
Description: Rabbit polyclonal TUBB3 antibody

TUBB3 cloning plasmid
CSB-CL623813HU-10ug 10ug
EUR 233
Description: A cloning plasmid for the TUBB3 gene.

Anti-TUBB3 antibody
STJ119330 100 µl
EUR 277

Anti-TUBB3 antibody
STJ119331 100 µl
EUR 277

Anti-TUBB3 antibody
STJ11100102 100 µl
EUR 393
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.

Anti-TUBB3 antibody
STJ113476 50 µl
EUR 287
Description: This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.

TUBB3 Monoclonal Antibody
30323-100ul 100ul
EUR 252

TUBB3 Monoclonal Antibody
30323-50ul 50ul
EUR 187

TUBB3 Polyclonal Antibody
A51998 100 µg
EUR 570.55
Description: kits suitable for this type of research

TUBB3 Polyclonal Antibody
A53965 100 µg
EUR 570.55
Description: Ask the seller for details

TUBB3 Mouse mAb
A18132-100ul 100 ul
EUR 384

TUBB3 Mouse mAb
A18132-20ul 20 ul
EUR 183

TUBB3 Mouse mAb
A18132-50ul 50 ul
EUR 265

TUBB3 Mouse mAb
A18132-200ul 200 ul
EUR 554

TUBB3 Rabbit pAb
A17073-100ul 100 ul
EUR 308

TUBB3 Rabbit pAb
A17073-200ul 200 ul
EUR 459

TUBB3 Rabbit pAb
A17073-20ul 20 ul
EUR 183

TUBB3 Rabbit pAb
A17073-50ul 50 ul
EUR 223

TUBB3 Rabbit pAb
A17074-100ul 100 ul
EUR 308

TUBB3 Rabbit pAb
A17074-200ul 200 ul
EUR 459

TUBB3 Rabbit pAb
A17074-20ul 20 ul
EUR 183

TUBB3 Rabbit pAb
A17074-50ul 50 ul
EUR 223

Anti-TUBB3 antibody
STJ72867 100 µg
EUR 359

TUBB3 Conjugated Antibody
C35539 100ul
EUR 397

TUBB3 Blocking Peptide
AF7000-BP 1mg
EUR 195

TUBB3 Blocking Peptide
BF0572-BP 1mg
EUR 195

anti-TUBB3 (2E9)
LF-MA30351 100 ul
EUR 486
Description: Mouse Monoclonal to TUBB3

TUBB3 specific antibody
PAab09890 100 ug
EUR 386

TUBB3 antibody (HRP)
60R-2074 100 ug
EUR 327
Description: Rabbit polyclonal TUBB3 antibody (HRP)

TUBB3 antibody (FITC)
60R-2075 100 ug
EUR 327
Description: Rabbit polyclonal TUBB3 antibody (FITC)

TUBB3 antibody (biotin)
60R-2076 100 ug
EUR 327
Description: Rabbit polyclonal TUBB3 antibody (biotin)

TUBB3 Antibody, HRP conjugated
1-CSB-PA03874B0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

TUBB3 Antibody, FITC conjugated
1-CSB-PA03874C0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

TUBB3 Antibody, Biotin conjugated
1-CSB-PA03874D0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

TUBB3 Antibody, HRP conjugated
1-CSB-PA03879B0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

TUBB3 Antibody, FITC conjugated
1-CSB-PA03879C0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

TUBB3 Antibody, Biotin conjugated
1-CSB-PA03879D0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Rat TUBB3 shRNA Plasmid
20-abx987934
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Mouse TUBB3 shRNA Plasmid
20-abx973259
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Human TUBB3 shRNA Plasmid
20-abx957032
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

TUBB3 Monoclonal Conjugated Antibody
C30323 100ul
EUR 397

anti- TUBB3 specific antibody
FNab09890 100µg
EUR 548.75
Description: Antibody raised against TUBB3 specific

Human TUBB3 ELISA Kit
ELA-E1638h 96 Tests
EUR 824

TUBB3 Recombinant Protein (Human)
RP033454 100 ug Ask for price

TUBB3 Recombinant Protein (Mouse)
RP182243 100 ug Ask for price

TUBB3 Recombinant Protein (Rat)
RP235280 100 ug Ask for price

TUBB3 protein (His tag)
80R-2700 50 ug
EUR 424
Description: Purified recombinant TUBB3 protein (His tag)

Recombinant Tubulin Beta 3 (TUBb3)
4-RPE711Hu01
  • EUR 512.16
  • EUR 240.00
  • EUR 1645.60
  • EUR 615.20
  • EUR 1130.40
  • EUR 406.00
  • EUR 3964.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Tubulin Beta 3 expressed in: E.coli

Polyclonal TUBB3 Antibody (N-term)
AMM05459G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TUBB3 (N-term). This antibody is tested and proven to work in the following applications:

Monoclonal TUBB3 Antibody, Clone: 2E9
APR13880G 0.1ml
EUR 484
Description: A Monoclonal antibody against Human TUBB3. The antibodies are raised in Mouse and are from clone 2E9. This antibody is applicable in WB, FC, ICC, E

Tubulin Beta 3 (TUBB3) Antibody
abx127119-50ul 50 ul
EUR 411

Tubulin, Beta 3 (TUBB3) Antibody
20-abx116351
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx121803
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx110304
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Tubulin Beta 3 (TUBB3) Antibody
20-abx110305
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Tubulin Beta 3 (TUBB3) Antibody
20-abx123449
  • EUR 592.00
  • EUR 857.00
  • EUR 217.00
  • EUR 411.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx002044
  • EUR 411.00
  • EUR 592.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx101413
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Tubulin Beta 3 (TUBB3) Antibody
abx036052-100ug 100 ug
EUR 391

beta 3-Tubulin (TUBB3) Antibody
20-abx134677
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx134678
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx134679
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx134680
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx134681
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

beta 3-Tubulin (TUBB3) Antibody
20-abx134682
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

Tubulin Beta 3 (TUBB3) Antibody
20-abx134683
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

beta III-Tubulin (TUBB3) Antibody
abx139401-01mg 0.1 mg
EUR 411

Tubulin Beta 3 (TUBB3) Antibody
abx012294-100ul 100 ul
EUR 411

Tubulin Beta 3 (TUBB3) Antibody
abx032605-400ul 400 ul
EUR 523