Successful Transition from Plasma Exchange to Eculizumab in Acetylcholine Receptor Antibody- and Muscle-Specific Kinase (MuSK) Antibody-Negative Myasthenia Gravis: A Case Report.

BACKGROUND The effectiveness of eculizumab (terminal complement inhibitor) at the acetylcholine receptor (AChR) antibody-negative general myasthenia gravis (GMG) is unknown. CASE REPORT A female patient was diagnosed with AChR-antibody and muscle-specific kinase (musk) antibody-negative GMG in March 2016. In January 2017, the patient was referred for plasma exchange (PLEX) because the symptoms continue.

He also received azathioprine, mycophenolate mofetil, and pyridostigmine (all continued during subsequent therapy). PLEX (5 sessions for 10 days) was initially effective, but over the next month PLEX patients received weekly, then twice a week, followed by 3 times a week for symptoms to worsen. In April 2018, PLEX reduced to two times a week following initiation of eculizumab (weekly induction dose of 900 mg 1 day after the first PLEX, plus 600 mg on day PLEX second session, for 4 weeks).

Patients then stabilized eculizumab 1200 mg every 2 weeks and PLEX treatment frequency reduced, until PLEX stopped on Sunday 39 after initiation of eculizumab. During eculizumab treatment, myasthenia gravis patients with activities of daily living (MG-ADL) scores decreased 9-1 or second most votes, with a temporary increase to 4 or 5 between Weeks 19 and 27 after eculizumab treatment less often. No side effects related to eculizumab.

CONCLUSION After the transition from three times a week PLEX for eculizumab in patients with treatment-refractory, AChR antibodies and antibody-negative musk GMG, there is clinically significant improvement in daily activities are affected by the symptoms of MG. Further investigation of eculizumab in antibody-negative MG necessary.

TUBB3
MBS200699-5x001mg 5x0.01mg
EUR 765

TUBB3
MBS8536962-01mL 0.1mL
EUR 325

TUBB3
MBS8536962-01mLAF405L 0.1mL(AF405L)
EUR 565

TUBB3
MBS8536962-01mLAF405S 0.1mL(AF405S)
EUR 565

TUBB3
MBS8536962-01mLAF610 0.1mL(AF610)
EUR 565

TUBB3
MBS8536962-01mLAF635 0.1mL(AF635)
EUR 565

TUBB3
pro-1388 2µg
EUR 60
Description: Recombinant Human Tubulin, Beta 3 Class III

TUBB3 Peptide
43-094P 0.1 mg
EUR 405.6
Description: TUBB3 Peptide

TUBB3 antibody
70R-15421 100 ug
EUR 302
Description: Rabbit polyclonal TUBB3 antibody

TUBB3 antibody
70R-21061 50 ul
EUR 289
Description: Rabbit polyclonal TUBB3 antibody

TUBB3 Antibody
35539 100ul
EUR 319

TUBB3 Antibody
35539-100ul 100ul
EUR 302.4

TUBB3 antibody
10R-8390 100 ul
EUR 499
Description: Mouse monoclonal TUBB3 antibody

TUBB3 antibody
10R-6182 100 ul
EUR 709
Description: Mouse monoclonal TUBB3 antibody

TUBB3 antibody
10R-10559 100 ug
EUR 420
Description: Mouse monoclonal TUBB3 antibody

TUBB3 antibody
10R-1824 100 ul
EUR 468
Description: Mouse monoclonal TUBB3 antibody

TUBB3 Antibody
1-CSB-PA917452
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  • 50ul
  • 100ul
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:500-1:5000, WB:1:500-1:1000, IHC:1:25-1:50

TUBB3 Antibody
CSB-PA884597- each
EUR 402
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

TUBB3 Antibody
CSB-PA884597-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

TUBB3 Antibody
1-CSB-PA000385
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  • 50ug
  • 100ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB;WB:1:2000-5000

TUBB3 Antibody
1-CSB-PA000393
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  • 50ug
  • 100ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB;WB:1:2000-5000

TUBB3 Antibody
1-CSB-PA025323GA01HU
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  • 50ul
  • 150ul
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

TUBB3 Antibody
1-CSB-PA03874A0Rb
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  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

TUBB3 Antibody
1-CSB-PA03879A0Rb
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  • 100ug
  • 50ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200

TUBB3 Antibody
CSB-PA675920XA01OFG-02mg 0.2mg Ask for price
Description: Recombinant Oryza sativa subsp. japonica (Rice) TUBB3 protein

TUBB3 Antibody
CSB-PA675920XA01OFG-10mg 10mg Ask for price
Description: Recombinant Oryza sativa subsp. japonica (Rice) TUBB3 protein

TUBB3 Antibody
CSB-PA675989XA01ZAX-02mg 0.2mg Ask for price
Description: Recombinant Zea mays (Maize) TUBB3 protein

TUBB3 Antibody
CSB-PA675989XA01ZAX-10mg 10mg Ask for price
Description: Recombinant Zea mays (Maize) TUBB3 protein

TUBB3 Antibody
1-CSB-PA004349
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  • 50ug
  • 100ug
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000

TUBB3 Antibody
CSB-PA220865XA01DOA-02mg 0.2mg Ask for price
Description: Recombinant Arabidopsis thaliana TUBB3 protein

TUBB3 Antibody
CSB-PA220865XA01DOA-10mg 10mg Ask for price
Description: Recombinant Arabidopsis thaliana TUBB3 protein

TUBB3 Antibody
E035539 100μg/100μl
EUR 255
Description: Available in various conjugation types.

TUBB3 Antibody
BF0572 200ul
EUR 540

TUBB3 Antibody
BF0572-100ul 100ul
EUR 210
Description: WB,IF/ICC,ELISA,FCM

TUBB3 Antibody
BF0572-200ul 200ul Ask for price
Description: WB,IF/ICC,ELISA,FCM

TUBB3 Antibody
BF0572-50ul 50ul
EUR 150
Description: WB,IF/ICC,ELISA,FCM

TUBB3 Antibody
AF7000 200ul
EUR 420

TUBB3 Antibody
AF7000-100ul 100ul
EUR 168
Description: WB,IF/ICC,ELISA(peptide)

TUBB3 Antibody
AF7000-200ul 200ul
EUR 210
Description: WB,IF/ICC,ELISA(peptide)

TUBB3 Antibody
CSB-PA969690- each
EUR 402
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

TUBB3 Antibody
CSB-PA969690-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against TUBB3. Recognizes TUBB3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:3000, IHC:1:50-1:100

TUBB3 Antibody
GWB-4D4EF5 0.1 ml Ask for price

TUBB3 Antibody
E92628 100μg
EUR 255
Description: Available in various conjugation types.

TUBB3 Antibody
E305253 100ug/200ul
EUR 275
Description: Available in various conjugation types.

TUBB3 Antibody
E10-20374 100μg/100μl
EUR 225
Description: Available in various conjugation types.

TUBB3 Antibody
GWB-MW982A 50ug Ask for price

TUBB3 Antibody
GWB-MW983B 50ug Ask for price

TUBB3 Antibody
E9C008 100ul
EUR 255
Description: Available in various conjugation types.

TUBB3 Antibody
MBS7132167-01mL 0.1mL
EUR 270

TUBB3 Antibody
MBS7132167-5x01mL 5x0.1mL
EUR 1200

TUBB3 Antibody
MBS7115640-005mg 0.05mg
EUR 150

TUBB3 Antibody
MBS7115640-01mg 0.1mg
EUR 190

TUBB3 Antibody
MBS7115640-5x01mg 5x0.1mg
EUR 845

TUBB3 Antibody
MBS7115647-005mg 0.05mg
EUR 150

TUBB3 Antibody
MBS7115647-01mg 0.1mg
EUR 190

TUBB3 Antibody
MBS7115647-5x01mg 5x0.1mg
EUR 845

TUBB3 Antibody
MBS7117197-005mg 0.05mg
EUR 150

TUBB3 Antibody
MBS7117197-01mg 0.1mg
EUR 190

TUBB3 Antibody
MBS7117197-5x01mg 5x0.1mg
EUR 845

TUBB3 Antibody
MBS7130508-01mL 0.1mL
EUR 270

TUBB3 Antibody
MBS7130508-5x01mL 5x0.1mL
EUR 1200

TUBB3 Antibody
MBS7123030-005mL 0.05mL
EUR 190

TUBB3 Antibody
MBS7123030-01mL 0.1mL
EUR 270

TUBB3 Antibody
MBS7123030-5x01mL 5x0.1mL
EUR 1205

TUBB3 Antibody
MBS850475-01mg 0.1mg
EUR 305

TUBB3 Antibody
MBS850475-01mLAF405L 0.1mL(AF405L)
EUR 565

TUBB3 Antibody
MBS850475-01mLAF405S 0.1mL(AF405S)
EUR 565

TUBB3 Antibody
MBS850475-01mLAF610 0.1mL(AF610)
EUR 565

TUBB3 Antibody
MBS850475-01mLAF635 0.1mL(AF635)
EUR 565

TUBB3 Antibody
MBS8500874-01mg 0.1mg
EUR 325

TUBB3 Antibody
MBS8500874-01mLAF405L 0.1mL(AF405L)
EUR 565

TUBB3 Antibody
MBS8500874-01mLAF405S 0.1mL(AF405S)
EUR 565

TUBB3 Antibody
MBS8500874-01mLAF610 0.1mL(AF610)
EUR 565

TUBB3 Antibody
MBS8500874-01mLAF635 0.1mL(AF635)
EUR 565

TUBB3 Antibody
MBS858082-01mg 0.1mg
EUR 345

TUBB3 Antibody
MBS858082-01mLAF405L 0.1mL(AF405L)
EUR 565

TUBB3 Antibody
MBS858082-01mLAF405S 0.1mL(AF405S)
EUR 565

TUBB3 Antibody
MBS858082-01mLAF610 0.1mL(AF610)
EUR 565

TUBB3 Antibody
MBS858082-01mLAF635 0.1mL(AF635)
EUR 565

TUBB3 Antibody
MBS9610362-01mL 0.1mL
EUR 260

TUBB3 Antibody
MBS9610362-02mL 0.2mL
EUR 305

TUBB3 Antibody
MBS9610362-5x02mL 5x0.2mL
EUR 1220

TUBB3 Antibody
MBS9414906-01mL 0.1mL
EUR 305

TUBB3 Antibody
MBS9414906-5x01mL 5x0.1mL
EUR 1230

Tubb3 (GFP-tagged) - Mouse tubulin, beta 3 (Tubb3)
MG207181 10 µg Ask for price

Tubb3 (untagged) - Mouse tubulin, beta 3 (Tubb3), (10ug)
MC201693 10 µg Ask for price

Tubb3 (Myc-DDK-tagged) - Mouse tubulin, beta 3 (Tubb3)
MR207181 10 µg Ask for price

TUBB3 Mouse mAb
A18132-100ul 100 ul
EUR 460.8

TUBB3 Mouse mAb
A18132-200ul 200 ul
EUR 664.8

TUBB3 Mouse mAb
A18132-20ul 20 ul
EUR 219.6

TUBB3 Mouse mAb
A18132-50ul 50 ul
EUR 318

Rat TUBB3 siRNA
20-abx938564
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  • 15 nmol
  • 30 nmol

TUBB3 Mouse mAb
E2220344 100ul
EUR 225
Description: Available in various conjugation types.

TUBB3 Mouse mAb
MBS8538554-01mL 0.1mL
EUR 305

TUBB3 Mouse mAb
MBS8538554-01mLAF405L 0.1mL(AF405L)
EUR 565

TUBB3 Mouse mAb
MBS8538554-01mLAF405S 0.1mL(AF405S)
EUR 565

TUBB3 Mouse mAb
MBS8538554-01mLAF610 0.1mL(AF610)
EUR 565

TUBB3 Mouse mAb
MBS8538554-01mLAF635 0.1mL(AF635)
EUR 565

TUBB3 siRNA (Rat)
MBS828626-15nmol 15nmol
EUR 405

TUBB3 siRNA (Rat)
MBS828626-30nmol 30nmol
EUR 565

TUBB3 siRNA (Rat)
MBS828626-5x30nmol 5x30nmol
EUR 2450

TUBB3 Rabbit pAb
A17073-100ul 100 ul
EUR 369.6

TUBB3 Rabbit pAb
A17073-200ul 200 ul
EUR 550.8

TUBB3 Rabbit pAb
A17073-20ul 20 ul
EUR 219.6

TUBB3 Rabbit pAb
A17073-50ul 50 ul
EUR 267.6

TUBB3 Rabbit pAb
A17074-100ul 100 ul
EUR 369.6

TUBB3 Rabbit pAb
A17074-200ul 200 ul
EUR 550.8

TUBB3 Rabbit pAb
A17074-20ul 20 ul
EUR 219.6

TUBB3 Rabbit pAb
A17074-50ul 50 ul
EUR 267.6

TUBB3 cDNA Clone
MBS1276474-001mgPlasmid02mLGlycerolStock 0.01mgPlasmid+0.2mLGlycerol-Stock
EUR 200

TUBB3 cDNA Clone
MBS1276474-5x001mgPlasmid5x02mLGlycerolStock 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock
EUR 855

Tubb3 Rabbit pAb
E47R2670 100ul
EUR 295

TUBB3 Rabbit pAb
E2517957 100ul
EUR 225
Description: Available in various conjugation types.

TUBB3 Rabbit pAb
E2540002 100ul
EUR 225
Description: Available in various conjugation types.

TUBB3 Rabbit pAb
MBS8550442-01mL 0.1mL
EUR 305

TUBB3 Rabbit pAb
MBS8550442-01mLAF405L 0.1mL(AF405L)
EUR 565

TUBB3 Rabbit pAb
MBS8550442-01mLAF405S 0.1mL(AF405S)
EUR 565

TUBB3 Rabbit pAb
MBS8550442-01mLAF610 0.1mL(AF610)
EUR 565

TUBB3 Rabbit pAb
MBS8550442-01mLAF635 0.1mL(AF635)
EUR 565

TUBB3 Rabbit pAb
MBS8550711-01mL 0.1mL
EUR 305

TUBB3 Rabbit pAb
MBS8550711-01mLAF405L 0.1mL(AF405L)
EUR 565

TUBB3 Rabbit pAb
MBS8550711-01mLAF405S 0.1mL(AF405S)
EUR 565

TUBB3 Rabbit pAb
MBS8550711-01mLAF610 0.1mL(AF610)
EUR 565

TUBB3 Rabbit pAb
MBS8550711-01mLAF635 0.1mL(AF635)
EUR 565

Tubb3 (untagged ORF) - Rat tubulin, beta 3 (Tubb3), (10 ug)
RN201784 10 µg Ask for price

Human TUBB3 siRNA
20-abx905870
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  • 15 nmol
  • 30 nmol

Mouse TUBB3 siRNA
20-abx938565
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  • 15 nmol
  • 30 nmol

TUBB3 siRNA (Mouse)
MBS8236036-15nmol 15nmol
EUR 405

TUBB3 siRNA (Mouse)
MBS8236036-30nmol 30nmol
EUR 565

TUBB3 siRNA (Mouse)
MBS8236036-5x30nmol 5x30nmol
EUR 2450

TUBB3 siRNA (Human)
MBS8207645-15nmol 15nmol
EUR 405

TUBB3 siRNA (Human)
MBS8207645-30nmol 30nmol
EUR 565

TUBB3 siRNA (Human)
MBS8207645-5x30nmol 5x30nmol
EUR 2450

TUBB3 antibody (HRP)
60R-2074 100 ug
EUR 302
Description: Rabbit polyclonal TUBB3 antibody (HRP)

TUBB3 antibody (HRP)
MBS5310548-01mg 0.1mg
EUR 510

TUBB3 antibody (HRP)
MBS5310548-5x01mg 5x0.1mg
EUR 2150

TUBB3 antibody (FITC)
60R-2075 100 ug
EUR 302
Description: Rabbit polyclonal TUBB3 antibody (FITC)

TUBB3 antibody (FITC)
MBS5310549-01mg 0.1mg
EUR 510

TUBB3 antibody (FITC)
MBS5310549-5x01mg 5x0.1mg
EUR 2150

TUBB3 Antibody Pair
MBS7041837-1PairSufficientfor5x96wellplates 1Pair(Sufficientfor5x96wellplates)
EUR 780

TUBB3 Antibody Pair
MBS7041837-5x1PairSufficientfor25x96wellplates 5x1Pair(Sufficientfor25x96wellplates)
EUR 3465

TUBB3 antibody (biotin)
60R-2076 100 ug
EUR 302
Description: Rabbit polyclonal TUBB3 antibody (biotin)

TUBB3 cloning plasmid
CSB-CL623813HU-10ug 10ug
EUR 279.6
Description: A cloning plasmid for the TUBB3 gene.

TUBB3 antibody (biotin)
MBS5310550-01mg 0.1mg
EUR 510