Background: The Cicadas Singers (hemiptera: cigadidae) of Bulgaria were poorly known. There are records published for 14 species: Cicada Orni, Lyrists Plebejus, Cicadatra Atra, Cicadatra Hyalina, Cicadatra Persica, Cicadatta Persica, Cicadetta Montana, Cicadetta Mediterranea, Timissaleta Dimissa, Oliglena Tibialis, Tympanistalis Gastrica, Pagiphora Annulata, Saiticula Coriaria, Tibicina Haematodes and Tibicina Steveni.
New information: Two species of this list were doubtful at the beginning of our study, because Tympanistalna Gastrica is distributed in the center and southern Portugal and Saiala Coriaria is a North African species. We have verified three main institutional collections hosted in Sofia, Bulgaria: the National Museum of Natural History (SOFM), the Institute of Zoology (ZISB) and the Faculty of Biology at Sofia University “St. Kliment ohridski »(BFU). We have confirmed 11 species mentioned in the literature, with the exception of Cicadetta Mediterranea and found two additional species: Cicadata Plassyptera and Cicadetta Macedonica (BFU specimens were confirmed bioacoustically).
Based on this knowledge, we still studied the Bulgaria’s singing cicadas with the use of morphological and bioacoustic methods in the years 2008, 2009, 2010, 2012, 2012, 2016 and 2019. We could not confirm the presence of Cicadata Persica and Cicadetta Mediterranea, but has Found three additional species: Cicadetta BreviNnis s. Lat., Cicadetta Cantilatrix and Tettettula Pygmea. Using bioacoustic methods, we also detected unknown song models, which could belong to three or four additional taxa, which must be described. The Bulgarian fauna of Cicada singing at the same time is composed of 16 potential species confirmed and 3-4.
SCN1A mutation spectrum in a cohort of Bulgarian patients at the GEFS + phenotype
BACKGROUND: Dravet syndrome (DS) is the most serious form of widespread epilepsy with febrile crisis syndrome and febrile supports (GEFS +) with a clear genetic component in 85% of cases. It is characterized by a seizure caused by fever of about six months and a deterioration of subsequent development later in life.
Methods: In the current study, 60 patients with crises and suspicions caused by fever, either FEMS + (50 patients) or DS (10 patients) were referred for the analysis of the SCN1A genes sequence.
Results: SCN1A Gene Sequencing revealed clinically significant variants in 11 patients (18.3%); Seven pathogens (11.7%) and four probable pathogens (6.7%). Five of these variants were not reported previously. Among the preselected group of ten DS patients, five had SCN1A pathogenic variants that confirmed the diagnosis of DS. In four patients with preliminary diagnosis GEFS +, the detected variant SCN1A allowed us to specify the diagnosis of DS in these patients. Thus, the SCN1A sequencing resulted in a confirmation of the 50% (5/10) genetic diagnosis of DS patients, as well as to clarify the diagnosis of DS in 8% of FEMS + patients (450). In this study, four patients with truncating mutations have had refractory crises and additional psychomotor anomalies. In addition, Missense pathogenic mutations have been detected in three children with comparable phenotypes, which favors observations that mutations despite critical channel function regions can cause a devastating epileptic disease.
Conclusions: This is the first systematic screening of the SCN1A gene in our country, which expands the spectrum of SCN1A variants with five new variants in Bulgaria and demonstrates the clinical utility of CNN1A confirmatory tests, which helps clinicians make Early and precise diagnoses. It is important for better monitoring, the choice of appropriate treatment, the prevention of the development of refractory seizures and neuropsychological complications. Identification of pathogenic variants in the SCN1A in the milder cases of FEMS + and serious DS, will help provide adequate prenatal diagnosis and improve genetic tips for affected families.
Respiratory symptoms of exposure to workplace substances among Bulgarian dentists
Objectives: Dentists are exposed to a variety of airborne chemicals that can serve as irritants and sensitizers and can give rise to work-related respiratory symptoms. The objective of this study was to estimate the prevalence of respiratory symptoms of exposure to workplace substances and risk factors involved in Bulgarian dentists.
Methods: A cross-sectional study was conducted among Bulgarian dentists using a self-recall questionnaire. A direct acyclic chart (DAG) has been developed to illustrate direct and indirect causal paths between exposure to irritants and / or allergens from the dental environment and work-related respiratory symptoms in dentists. A multiple logistic regression analysis was performed to study the relationship between sex, work experience, daily exposure to chemicals from the dental environment, a history of atopic disorders and respiratory symptoms related to the job.
Results: A total of 4675 dentists completed the questionnaire (response rate 48.1%). The prevalence of self-reported respiratory symptoms was 20.7%. The most commonly repeated causes of respiratory reactions were disinfectants (65.7%) and materials based on acrylic resins (29.7%). Factors associated with work-related respiratory symptoms are a personal history of confidence interval of asthma, work experience> 20 years and female sex.
) Phenolic Compounds Assay Kit (Colorimetric) |
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| K527-200 | Biovision | EUR 550 | |
 Epoxy Magnetic Particles |
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| EM-05-10 | Spherotech | 10 mL | EUR 223 |
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Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. |
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Epoxy Magnetic Particles |
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| EM-20-10 | Spherotech | 10 mL | EUR 223 |
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Description: Epoxy Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team. |
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Epoxy Magnetic Particles |
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| EM-20-100 | Spherotech | 100 mL | EUR 1430 |
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Description: Epoxy Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team. |
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 c6010 kit epoxy ec |
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| C6010KE | Consort | ea | EUR 677 |
 c6010 kit epoxy ph |
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| C6010PE | Consort | ea | EUR 663 |
 c6030 kit epoxy ph |
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| C6030PE | Consort | ea | EUR 900 |
 c3010 kit epoxy ph |
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| C3010PE | Consort | ea | EUR 746 |
 c3030 kit epoxy ph |
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| C3030PE | Consort | ea | EUR 1033 |
 NuGel™ Poly-Epoxy |
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| NPEY-25 | Biotech Support Group | 25 Grams | EUR 466 |
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Description: NuGel™ Immobilization Reagent |
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 MBHA resin |
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| 20-abx095143 | Abbexa |
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 Merrifield resin |
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| 20-abx095147 | Abbexa |
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 Wang resin |
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| 20-abx095148 | Abbexa |
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 AM resin |
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| 20-abx095149 | Abbexa |
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 Wang Resin |
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| A6776-100000 | ApexBio | 100 g | EUR 200 |
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Description: Wang Resin |
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Wang Resin |
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| A6776-25000 | ApexBio | 25 g | EUR 125 |
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Description: Wang Resin |
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 DiagNano Epoxy Silica Particles, 300 nm |
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| DNG-F062 | Creative Diagnostics | 100 mg | EUR 569 |
 DiagNano Epoxy Silica Particles, 500 nm |
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| DNG-F063 | Creative Diagnostics | 100 mg | EUR 569 |
 DiagNano Epoxy Silica Particles, 1 μm |
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| DNG-F064 | Creative Diagnostics | 100 mg | EUR 585 |
 DiagNano Epoxy Silica Particles, 1.5 μm |
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| DNG-F065 | Creative Diagnostics | 100 mg | EUR 601 |
 DiagNano Epoxy Silica Particles, 3 μm |
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| DNG-F066 | Creative Diagnostics | 100 mg | EUR 569 |
 DiagNano Epoxy Silica Particles, 4 μm |
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| DNG-F067 | Creative Diagnostics | 100 mg | EUR 569 |
 DiagNano Epoxy Silica Particles, 5 μm |
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| DNG-F068 | Creative Diagnostics | 100 mg | EUR 569 |
 DiagNano Epoxy Silica Particles, 10 μm |
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| DNG-F069 | Creative Diagnostics | 100 mg | EUR 601 |
 DiagNano Epoxy Silica Particles, 15 μm |
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| DNG-F070 | Creative Diagnostics | 100 mg | EUR 601 |
 DiagNano Epoxy Silica Particles, 20 μm |
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| DNG-F071 | Creative Diagnostics | 100 mg | EUR 601 |
 DiagPoly Epoxy Polystyrene Particles, 30 μm |
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| DNM-M001 | Creative Diagnostics | 10 mL | EUR 771 |
 Aminomethyl Polystyrene Resin |
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| 5-08191 | CHI Scientific | 25g | Ask for price |
Aminomethyl Polystyrene Resin |
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| 5-08192 | CHI Scientific | 100g | Ask for price |
Aminomethyl Polystyrene Resin |
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| 5-08193 | CHI Scientific | 25g | Ask for price |
Aminomethyl Polystyrene Resin |
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| 5-08194 | CHI Scientific | 100g | Ask for price |
 Glutathione Agarose Resin |
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| 4B-GLU-10 | ABTBeads | 10 ml | EUR 173 |
Glutathione Agarose Resin |
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| 4B-GLU-100 | ABTBeads | 100 ml | EUR 996 |
 Biotin Agarose Resin |
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| 4BCL-BI-10 | ABTBeads | 10 ml | EUR 411 |
Biotin Agarose Resin |
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| 4BCL-BI-5 | ABTBeads | 5 ml | EUR 235 |
 Ni-NTA Resin |
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| 20-abx098108 | Abbexa |
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 Ni-IDA Resin |
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| 20-abx098109 | Abbexa |
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 Protein A Resin |
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| abx098111-5ml | Abbexa | 5 ml | EUR 398 |
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 Protein G Resin |
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| abx098112-5ml | Abbexa | 5 ml | EUR 439 |
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 MP-EDC resin |
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| 20-abx095129 | Abbexa |
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 MP-TEMPO resin |
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| 20-abx095130 | Abbexa |
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 MP-Aminomethyl resin |
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| 20-abx095132 | Abbexa |
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 MP-Acetylacetone resin |
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| 20-abx095133 | Abbexa |
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 MP-Piperazinomethyl resin |
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| 20-abx095134 | Abbexa |
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 MP-Diethylenetriamine resin |
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| 20-abx095136 | Abbexa |
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 MP-Carbonate resin |
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| 20-abx095138 | Abbexa |
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 MP-Morpholinomethyl resin |
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| 20-abx095139 | Abbexa |
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 MP-Thiosulfate resin |
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| 20-abx095140 | Abbexa |
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 MP-Mercaptomethyl resin |
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| abx095141-100g | Abbexa | 100 g | EUR 509 |
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 MP-TMT resin |
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| 20-abx095142 | Abbexa |
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 Rink Amide Resin |
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| A6576-100000 | ApexBio | 100 g | EUR 947 |
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Description: Rink resin is originally developed for SPS of peptide amides. Now the scope of its application is extended from carboxylic amides to the immobilization of amines, substituted amides. |
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Rink Amide Resin |
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| A6576-25000 | ApexBio | 25 g | EUR 299 |
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Description: Rink resin is originally developed for SPS of peptide amides. Now the scope of its application is extended from carboxylic amides to the immobilization of amines, substituted amides. |
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 DHP HM Resin |
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| A6789-100000 | ApexBio | 100 g | EUR 514 |
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Description: DHP HM Resin |
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DHP HM Resin |
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| A6789-25000 | ApexBio | 25 g | EUR 203 |
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Description: DHP HM Resin |
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 GST-Sefinose Resin |
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| BSP031 | Bio Basic | 5ml | EUR 145.7 |
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GST-Sefinose Resin |
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| BSP031-1 | Bio Basic | 25ml | EUR 415.4 |
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 c6030 kit epoxy ec/tds/sal/res |
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| C6030KE | Consort | ea | EUR 913 |
 c3010 kit epoxy ec/tds/sal/res |
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| C3010KE | Consort | ea | EUR 759 |
 c3030 kit epoxy ec/tds/sal/res |
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| C3030KE | Consort | ea | EUR 1047 |
 Nickel NTA Agarose Resin |
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| 6BCL-NTANi-100 | ABTBeads | 100 ml | EUR 651 |
Nickel NTA Agarose Resin |
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| 6BCL-NTANi-25 | ABTBeads | 25 ml | EUR 217 |
Nickel NTA Agarose Resin |
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| 6BCL-NTANi-500 | ABTBeads | 500 ml | EUR 2584 |
 Fmoc-Ala-Wang resin |
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| 5-07835 | CHI Scientific | 5g | Ask for price |
Fmoc-Ala-Wang resin |
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| 5-07836 | CHI Scientific | 25g | Ask for price |
 Fmoc-Acp-Wang resin |
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| 5-07841 | CHI Scientific | 5g | Ask for price |
Fmoc-Acp-Wang resin |
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| 5-07842 | CHI Scientific | 25g | Ask for price |
 Fmoc-Cha-Wang Resin |
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| 5-07863 | CHI Scientific | 5g | Ask for price |
Fmoc-Cha-Wang Resin |
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| 5-07864 | CHI Scientific | 25g | Ask for price |
 Fmoc-Cit-Wang resin |
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| 5-07867 | CHI Scientific | 5g | Ask for price |
Fmoc-Cit-Wang resin |
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| 5-07868 | CHI Scientific | 25g | Ask for price |
 Fmoc-Gly-Wang resin |
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| 5-07891 | CHI Scientific | 5g | Ask for price |
Fmoc-Gly-Wang resin |
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| 5-07892 | CHI Scientific | 25g | Ask for price |
Fmoc-Gly-Wang resin |
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| 5-07893 | CHI Scientific | 5g | Ask for price |
Fmoc-Gly-Wang resin |
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| 5-07894 | CHI Scientific | 25g | Ask for price |
 Fmoc-Ile-Wang resin |
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| 5-07899 | CHI Scientific | 5g | Ask for price |
Fmoc-Ile-Wang resin |
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| 5-07900 | CHI Scientific | 25g | Ask for price |
 Fmoc-Leu-Wang resin |
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| 5-07903 | CHI Scientific | 5g | Ask for price |
Fmoc-Leu-Wang resin |
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| 5-07904 | CHI Scientific | 25g | Ask for price |
Fmoc-Leu-Wang resin |
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| 5-07905 | CHI Scientific | 5g | Ask for price |
Fmoc-Leu-Wang resin |
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| 5-07906 | CHI Scientific | 25g | Ask for price |
 Fmoc-Lys-Wang resin |
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| 5-07907 | CHI Scientific | 5g | Ask for price |
Fmoc-Lys-Wang resin |
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| 5-07908 | CHI Scientific | 25g | Ask for price |
 Fmoc-Met-Wang resin |
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| 5-07923 | CHI Scientific | 5g | Ask for price |
Fmoc-Met-Wang resin |
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| 5-07924 | CHI Scientific | 25g | Ask for price |
 Fmoc-Phe-Wang resin |
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| 5-07929 | CHI Scientific | 5g | Ask for price |
Fmoc-Phe-Wang resin |
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| 5-07930 | CHI Scientific | 25g | Ask for price |
Fmoc-Phe-Wang resin |
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| 5-07931 | CHI Scientific | 5g | Ask for price |
Fmoc-Phe-Wang resin |
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| 5-07932 | CHI Scientific | 25g | Ask for price |
 Fmoc-Pro-Wang resin |
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| 5-07947 | CHI Scientific | 5g | Ask for price |
Fmoc-Pro-Wang resin |
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| 5-07948 | CHI Scientific | 25g | Ask for price |
Fmoc-Pro-Wang resin |
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| 5-07949 | CHI Scientific | 5g | Ask for price |
Fmoc-Pro-Wang resin |
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| 5-07950 | CHI Scientific | 25g | Ask for price |
 Fmoc-Tle-Wang Resin |
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| 5-07965 | CHI Scientific | 5g | Ask for price |
Fmoc-Tle-Wang Resin |
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| 5-07966 | CHI Scientific | 25g | Ask for price |
 Fmoc-Thr-Wang resin |
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| 5-07967 | CHI Scientific | 5g | Ask for price |
Fmoc-Thr-Wang resin |
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| 5-07968 | CHI Scientific | 25g | Ask for price |
 Fmoc-Trp-Wang resin |
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| 5-07975 | CHI Scientific | 5g | Ask for price |
Fmoc-Trp-Wang resin |
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| 5-07976 | CHI Scientific | 25g | Ask for price |
 Fmoc-Val-Wang resin |
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| 5-07989 | CHI Scientific | 5g | Ask for price |
Fmoc-Val-Wang resin |
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| 5-07990 | CHI Scientific | 25g | Ask for price |
 2-Chlorotrityl Chloride Resin |
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| 5-08183 | CHI Scientific | 25g | Ask for price |
2-Chlorotrityl Chloride Resin |
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| 5-08184 | CHI Scientific | 100g | Ask for price |
2-Chlorotrityl Chloride Resin |
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| 5-08185 | CHI Scientific | 25g | Ask for price |
2-Chlorotrityl Chloride Resin |
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| 5-08186 | CHI Scientific | 100g | Ask for price |
 Fmoc-Leu-Tcp Resin |
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| 5-08289 | CHI Scientific | 5g | Ask for price |
Fmoc-Leu-Tcp Resin |
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| 5-08290 | CHI Scientific | 25g | Ask for price |
 Protein A-Agarose Resin |
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| 55000 | AAT Bioquest | 1 mL | EUR 132 |
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Protein A-Agarose Resin |
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| 55005 | AAT Bioquest | 5 mL | EUR 306 |
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 Protein L Agarose Resin |
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| 4BCLPL-10 | ABTBeads | 10 ml | EUR 393 |
Protein L Agarose Resin |
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| 4BCLPL-2 | ABTBeads | 2 ml | EUR 197 |
Protein L Agarose Resin |
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| 4BCLPL-5 | ABTBeads | 5 ml | EUR 284 |
Fmoc-Gly-Wang resin |
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| 20-abx095122 | Abbexa |
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 MP-Sulfonic acid resin |
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| 20-abx095135 | Abbexa |
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 2-Chlorotrityl Chloride resin |
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| 20-abx095137 | Abbexa |
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 Rink Amide AM resin |
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| 20-abx095146 | Abbexa |
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 Rink Amide-AM Resin |
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| A6780-100000 | ApexBio | 100 g | EUR 727 |
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Description: Rink Amide-AM Resin |
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Rink Amide-AM Resin |
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| A6780-25000 | ApexBio | 25 g | EUR 389 |
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Description: Rink Amide-AM Resin |
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Rink Amide-AM Resin |
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| A6780-5000 | ApexBio | 5 g | EUR 219 |
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Description: Rink Amide-AM Resin |
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2-Chlorotrityl Chloride Resin |
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| A6791-100000 | ApexBio | 100 g | EUR 328 |
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Description: 2-Chlorotrityl Chloride Resin |
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2-Chlorotrityl Chloride Resin |
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| A6791-25000 | ApexBio | 25 g | EUR 142 |
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Description: 2-Chlorotrityl Chloride Resin |
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Fmoc-Phe-Wang resin |
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| A6831-25000 | ApexBio | 25 g | EUR 205 |
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Description: Fmoc-Phe-Wang resin |
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Fmoc-Phe-Wang resin |
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| A6831-5000 | ApexBio | 5 g | EUR 87 |
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Description: Fmoc-Phe-Wang resin |
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Fmoc-Ile-Wang resin |
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| A6836-25000 | ApexBio | 25 g | EUR 205 |
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Description: Fmoc-Ile-Wang resin |
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Fmoc-Ile-Wang resin |
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| A6836-5000 | ApexBio | 5 g | EUR 87 |
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Description: Fmoc-Ile-Wang resin |
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Fmoc-Gly-Wang resin |
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| A6839-25000 | ApexBio | 25 g | EUR 205 |
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Description: Fmoc-Gly-Wang resin |
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Fmoc-Gly-Wang resin |
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| A6839-5000 | ApexBio | 5 g | EUR 87 |
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Description: Fmoc-Gly-Wang resin |
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 Protein A Agarose Resin |
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| PA09-100 | ABTBeads | 100 ml | EUR 2094 |
Protein A Agarose Resin |
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| PA09-25 | ABTBeads | 25 ml | EUR 925 |
Protein A Agarose Resin |
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| PA09-5 | ABTBeads | 5 ml | EUR 291 |
 Streptavidin 6HC Agarose Resin |
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| STV6HC-10 | ABTBeads | 10 ml | EUR 399 |
Streptavidin 6HC Agarose Resin |
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| STV6HC-20 | ABTBeads | 20 ml | EUR 685 |
Streptavidin 6HC Agarose Resin |
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| STV6HC-5 | ABTBeads | 5 ml | EUR 237 |
Protein A Agarose Resin |
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| BSP095-7 | Bio Basic | 1ml | EUR 93.5 |
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Protein A Agarose Resin |
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| BSP095-8 | Bio Basic | 5ml | EUR 245.75 |
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 Protein A Sefinose Resin |
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| BSP096-25 | Bio Basic | 12.5ml | EUR 702.5 |
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Protein A Sefinose Resin |
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| BSP096-5 | Bio Basic | 2.5ml | EUR 193.55 |
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 Protein G Agarose Resin |
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| SF022-PG | Bio Basic | 5ml | EUR 775 |
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 c6010 kit epoxy ph/ec/tds/sal/res |
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| C6010PKE | Consort | ea | EUR 766 |
 c6030 kit epoxy ph/ec/tds/sal/res |
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| C6030PKE | Consort | ea | EUR 1003 |
 c3010 kit epoxy ph/ec/tds/sal/res |
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| C3010PKE | Consort | ea | EUR 849 |
 c3030 kit epoxy ph/ec/tds/sal/res |
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| C3030PKE | Consort | ea | EUR 1136 |
 Absolute Mag Epoxy Silica Magnetic Particles, 1.5 µm |
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| SMP-UM05 | Creative Diagnostics | 500 mg | EUR 814 |
 Absolute Mag Epoxy Silica Magnetic Particles, 6 µm |
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| SMP-UM18 | Creative Diagnostics | 500 mg | EUR 720 |
 2-Carboxymethyl-3-preny-2,3-epoxy-1,4-naphthoquinone |
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| TBZ0135 | ChemNorm | unit | Ask for price |
 Absolute Mag Epoxy Magnetic Particles, 0.5-1.0 μm |
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| WHM-Q075 | Creative Diagnostics | 10 mL | EUR 559 |
 Absolute Mag Epoxy Magnetic Particles, 1.0-2.0 μm |
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| WHM-Q076 | Creative Diagnostics | 10 mL | EUR 559 |
 Absolute Mag Epoxy Magnetic Particles, 2.0-3.0 μm |
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| WHM-Q077 | Creative Diagnostics | 10 mL | EUR 559 |
Conclusion: Work-related respiratory symptoms are common among dentists and indicate efforts to establish effective programs and techniques for reducing or eliminating direct exposure to chemicals in the air in the dental environment.