Checklist and provisional atlas of singing cicadas (Hemiptera: Cicadidae) of Bulgaria, based on bioacoustics

Background: The Cicadas Singers (hemiptera: cigadidae) of Bulgaria were poorly known. There are records published for 14 species: Cicada Orni, Lyrists Plebejus, Cicadatra Atra, Cicadatra Hyalina, Cicadatra Persica, Cicadatta Persica, Cicadetta Montana, Cicadetta Mediterranea, Timissaleta Dimissa, Oliglena Tibialis, Tympanistalis Gastrica, Pagiphora Annulata, Saiticula Coriaria, Tibicina Haematodes and Tibicina Steveni.

New information: Two species of this list were doubtful at the beginning of our study, because Tympanistalna Gastrica is distributed in the center and southern Portugal and Saiala Coriaria is a North African species. We have verified three main institutional collections hosted in Sofia, Bulgaria: the National Museum of Natural History (SOFM), the Institute of Zoology (ZISB) and the Faculty of Biology at Sofia University “St. Kliment ohridski »(BFU). We have confirmed 11 species mentioned in the literature, with the exception of Cicadetta Mediterranea and found two additional species: Cicadata Plassyptera and Cicadetta Macedonica (BFU specimens were confirmed bioacoustically).

Based on this knowledge, we still studied the Bulgaria’s singing cicadas with the use of morphological and bioacoustic methods in the years 2008, 2009, 2010, 2012, 2012, 2016 and 2019. We could not confirm the presence of Cicadata Persica and Cicadetta Mediterranea, but has Found three additional species: Cicadetta BreviNnis s. Lat., Cicadetta Cantilatrix and Tettettula Pygmea. Using bioacoustic methods, we also detected unknown song models, which could belong to three or four additional taxa, which must be described. The Bulgarian fauna of Cicada singing at the same time is composed of 16 potential species confirmed and 3-4.

 

SCN1A mutation spectrum in a cohort of Bulgarian patients at the GEFS + phenotype

BACKGROUND: Dravet syndrome (DS) is the most serious form of widespread epilepsy with febrile crisis syndrome and febrile supports (GEFS +) with a clear genetic component in 85% of cases. It is characterized by a seizure caused by fever of about six months and a deterioration of subsequent development later in life.

Methods: In the current study, 60 patients with crises and suspicions caused by fever, either FEMS + (50 patients) or DS (10 patients) were referred for the analysis of the SCN1A genes sequence.

Results: SCN1A Gene Sequencing revealed clinically significant variants in 11 patients (18.3%); Seven pathogens (11.7%) and four probable pathogens (6.7%). Five of these variants were not reported previously. Among the preselected group of ten DS patients, five had SCN1A pathogenic variants that confirmed the diagnosis of DS. In four patients with preliminary diagnosis GEFS +, the detected variant SCN1A allowed us to specify the diagnosis of DS in these patients. Thus, the SCN1A sequencing resulted in a confirmation of the 50% (5/10) genetic diagnosis of DS patients, as well as to clarify the diagnosis of DS in 8% of FEMS + patients (450). In this study, four patients with truncating mutations have had refractory crises and additional psychomotor anomalies. In addition, Missense pathogenic mutations have been detected in three children with comparable phenotypes, which favors observations that mutations despite critical channel function regions can cause a devastating epileptic disease.

Conclusions: This is the first systematic screening of the SCN1A gene in our country, which expands the spectrum of SCN1A variants with five new variants in Bulgaria and demonstrates the clinical utility of CNN1A confirmatory tests, which helps clinicians make Early and precise diagnoses. It is important for better monitoring, the choice of appropriate treatment, the prevention of the development of refractory seizures and neuropsychological complications. Identification of pathogenic variants in the SCN1A in the milder cases of FEMS + and serious DS, will help provide adequate prenatal diagnosis and improve genetic tips for affected families.

 Checklist and provisional atlas of singing cicadas (Hemiptera: Cicadidae) of Bulgaria, based on bioacoustics
Checklist and provisional atlas of singing cicadas (Hemiptera: Cicadidae) of Bulgaria, based on bioacoustics

Respiratory symptoms of exposure to workplace substances among Bulgarian dentists

Objectives: Dentists are exposed to a variety of airborne chemicals that can serve as irritants and sensitizers and can give rise to work-related respiratory symptoms. The objective of this study was to estimate the prevalence of respiratory symptoms of exposure to workplace substances and risk factors involved in Bulgarian dentists.

Methods: A cross-sectional study was conducted among Bulgarian dentists using a self-recall questionnaire. A direct acyclic chart (DAG) has been developed to illustrate direct and indirect causal paths between exposure to irritants and / or allergens from the dental environment and work-related respiratory symptoms in dentists. A multiple logistic regression analysis was performed to study the relationship between sex, work experience, daily exposure to chemicals from the dental environment, a history of atopic disorders and respiratory symptoms related to the job.

Results: A total of 4675 dentists completed the questionnaire (response rate 48.1%). The prevalence of self-reported respiratory symptoms was 20.7%. The most commonly repeated causes of respiratory reactions were disinfectants (65.7%) and materials based on acrylic resins (29.7%). Factors associated with work-related respiratory symptoms are a personal history of confidence interval of asthma, work experience> 20 years and female sex.

 

Phenolic Compounds Assay Kit (Colorimetric)

K527-200
EUR 550

Epoxy Magnetic Particles

EM-05-10 10 mL
EUR 223
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Epoxy Magnetic Particles

EM-20-10 10 mL
EUR 223
Description: Epoxy Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

Epoxy Magnetic Particles

EM-20-100 100 mL
EUR 1430
Description: Epoxy Magnetic Particles are prepared by coating a layer of magnetite and polystyrene onto monodispersed (i.e.. uniform sized) polystyrene core particles. The magnetic particles can be easily separated from a suspension magnetically. These particles become non magnetic when removed from a magnet, and do not retain any detectable magnetism even after repeated exposure to strong magnetic field.Are of research that those particles had been tested are cell separation, affinity purification, DNA probe assays, magnetic particle EIA. For more infomation please don't hesiate to contact our technical team.

c6010 kit epoxy ec

C6010KE ea
EUR 677

c6010 kit epoxy ph

C6010PE ea
EUR 663

c6030 kit epoxy ph

C6030PE ea
EUR 900

c3010 kit epoxy ph

C3010PE ea
EUR 746

c3030 kit epoxy ph

C3030PE ea
EUR 1033

NuGel™ Poly-Epoxy

NPEY-25 25 Grams
EUR 466
Description: NuGel™ Immobilization Reagent

MBHA resin

20-abx095143
  • EUR 495.00
  • EUR 2305.00
  • EUR 885.00
  • EUR 244.00
  • EUR 1497.00
  • 100 g
  • 1 kg
  • 250 g
  • 25 g
  • 500 g
  • Shipped within 5-10 working days.

Merrifield resin

20-abx095147
  • EUR 217.00
  • EUR 356.00
  • EUR 523.00
  • 100 g
  • 250 g
  • 500 g
  • Shipped within 5-10 working days.

Wang resin

20-abx095148
  • EUR 314.00
  • EUR 523.00
  • EUR 885.00
  • 100 g
  • 250 g
  • 500 g
  • Shipped within 5-10 working days.

AM resin

20-abx095149
  • EUR 314.00
  • EUR 592.00
  • EUR 885.00
  • 100 g
  • 250 g
  • 500 g
  • Shipped within 5-10 working days.

Wang Resin

A6776-100000 100 g
EUR 200
Description: Wang Resin

Wang Resin

A6776-25000 25 g
EUR 125
Description: Wang Resin

DiagNano Epoxy Silica Particles, 300 nm

DNG-F062 100 mg
EUR 569

DiagNano Epoxy Silica Particles, 500 nm

DNG-F063 100 mg
EUR 569

DiagNano Epoxy Silica Particles, 1 μm

DNG-F064 100 mg
EUR 585

DiagNano Epoxy Silica Particles, 1.5 μm

DNG-F065 100 mg
EUR 601

DiagNano Epoxy Silica Particles, 3 μm

DNG-F066 100 mg
EUR 569

DiagNano Epoxy Silica Particles, 4 μm

DNG-F067 100 mg
EUR 569

DiagNano Epoxy Silica Particles, 5 μm

DNG-F068 100 mg
EUR 569

DiagNano Epoxy Silica Particles, 10 μm

DNG-F069 100 mg
EUR 601

DiagNano Epoxy Silica Particles, 15 μm

DNG-F070 100 mg
EUR 601

DiagNano Epoxy Silica Particles, 20 μm

DNG-F071 100 mg
EUR 601

DiagPoly Epoxy Polystyrene Particles, 30 μm

DNM-M001 10 mL
EUR 771

Aminomethyl Polystyrene Resin

5-08191 25g Ask for price

Aminomethyl Polystyrene Resin

5-08192 100g Ask for price

Aminomethyl Polystyrene Resin

5-08193 25g Ask for price

Aminomethyl Polystyrene Resin

5-08194 100g Ask for price

Glutathione Agarose Resin

4B-GLU-10 10 ml
EUR 173

Glutathione Agarose Resin

4B-GLU-100 100 ml
EUR 996

Biotin Agarose Resin

4BCL-BI-10 10 ml
EUR 411

Biotin Agarose Resin

4BCL-BI-5 5 ml
EUR 235

Ni-NTA Resin

20-abx098108
  • EUR 509.00
  • EUR 244.00
  • 25 ml
  • 5 ml
  • Shipped within 5-10 working days.

Ni-IDA Resin

20-abx098109
  • EUR 453.00
  • EUR 230.00
  • 25 ml
  • 5 ml
  • Shipped within 5-10 working days.

Protein A Resin

abx098111-5ml 5 ml
EUR 398
  • Shipped within 5-10 working days.

Protein G Resin

abx098112-5ml 5 ml
EUR 439
  • Shipped within 5-10 working days.

MP-EDC resin

20-abx095129
  • EUR 1052.00
  • EUR 439.00
  • EUR 217.00
  • 100 g
  • 25 g
  • 5 g
  • Shipped within 5-10 working days.

MP-TEMPO resin

20-abx095130
  • EUR 1052.00
  • EUR 439.00
  • EUR 217.00
  • 100 g
  • 25 g
  • 5 g
  • Shipped within 5-10 working days.

MP-Aminomethyl resin

20-abx095132
  • EUR 328.00
  • EUR 189.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

MP-Acetylacetone resin

20-abx095133
  • EUR 439.00
  • EUR 230.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

MP-Piperazinomethyl resin

20-abx095134
  • EUR 439.00
  • EUR 230.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

MP-Diethylenetriamine resin

20-abx095136
  • EUR 453.00
  • EUR 230.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

MP-Carbonate resin

20-abx095138
  • EUR 467.00
  • EUR 244.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

MP-Morpholinomethyl resin

20-abx095139
  • EUR 467.00
  • EUR 244.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

MP-Thiosulfate resin

20-abx095140
  • EUR 467.00
  • EUR 244.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

MP-Mercaptomethyl resin

abx095141-100g 100 g
EUR 509
  • Shipped within 5-10 working days.

MP-TMT resin

20-abx095142
  • EUR 578.00
  • EUR 272.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

Rink Amide Resin

A6576-100000 100 g
EUR 947
Description: Rink resin is originally developed for SPS of peptide amides. Now the scope of its application is extended from carboxylic amides to the immobilization of amines, substituted amides.

Rink Amide Resin

A6576-25000 25 g
EUR 299
Description: Rink resin is originally developed for SPS of peptide amides. Now the scope of its application is extended from carboxylic amides to the immobilization of amines, substituted amides.

DHP HM Resin

A6789-100000 100 g
EUR 514
Description: DHP HM Resin

DHP HM Resin

A6789-25000 25 g
EUR 203
Description: DHP HM Resin

GST-Sefinose Resin

BSP031 5ml
EUR 145.7
  • Product category: Biochemicals/Biology Reagents/Protein Related

GST-Sefinose Resin

BSP031-1 25ml
EUR 415.4
  • Product category: Biochemicals/Biology Reagents/Protein Related

c6030 kit epoxy ec/tds/sal/res

C6030KE ea
EUR 913

c3010 kit epoxy ec/tds/sal/res

C3010KE ea
EUR 759

c3030 kit epoxy ec/tds/sal/res

C3030KE ea
EUR 1047

Nickel NTA Agarose Resin

6BCL-NTANi-100 100 ml
EUR 651

Nickel NTA Agarose Resin

6BCL-NTANi-25 25 ml
EUR 217

Nickel NTA Agarose Resin

6BCL-NTANi-500 500 ml
EUR 2584

Fmoc-Ala-Wang resin

5-07835 5g Ask for price

Fmoc-Ala-Wang resin

5-07836 25g Ask for price

Fmoc-Acp-Wang resin

5-07841 5g Ask for price

Fmoc-Acp-Wang resin

5-07842 25g Ask for price

Fmoc-Cha-Wang Resin

5-07863 5g Ask for price

Fmoc-Cha-Wang Resin

5-07864 25g Ask for price

Fmoc-Cit-Wang resin

5-07867 5g Ask for price

Fmoc-Cit-Wang resin

5-07868 25g Ask for price

Fmoc-Gly-Wang resin

5-07891 5g Ask for price

Fmoc-Gly-Wang resin

5-07892 25g Ask for price

Fmoc-Gly-Wang resin

5-07893 5g Ask for price

Fmoc-Gly-Wang resin

5-07894 25g Ask for price

Fmoc-Ile-Wang resin

5-07899 5g Ask for price

Fmoc-Ile-Wang resin

5-07900 25g Ask for price

Fmoc-Leu-Wang resin

5-07903 5g Ask for price

Fmoc-Leu-Wang resin

5-07904 25g Ask for price

Fmoc-Leu-Wang resin

5-07905 5g Ask for price

Fmoc-Leu-Wang resin

5-07906 25g Ask for price

Fmoc-Lys-Wang resin

5-07907 5g Ask for price

Fmoc-Lys-Wang resin

5-07908 25g Ask for price

Fmoc-Met-Wang resin

5-07923 5g Ask for price

Fmoc-Met-Wang resin

5-07924 25g Ask for price

Fmoc-Phe-Wang resin

5-07929 5g Ask for price

Fmoc-Phe-Wang resin

5-07930 25g Ask for price

Fmoc-Phe-Wang resin

5-07931 5g Ask for price

Fmoc-Phe-Wang resin

5-07932 25g Ask for price

Fmoc-Pro-Wang resin

5-07947 5g Ask for price

Fmoc-Pro-Wang resin

5-07948 25g Ask for price

Fmoc-Pro-Wang resin

5-07949 5g Ask for price

Fmoc-Pro-Wang resin

5-07950 25g Ask for price

Fmoc-Tle-Wang Resin

5-07965 5g Ask for price

Fmoc-Tle-Wang Resin

5-07966 25g Ask for price

Fmoc-Thr-Wang resin

5-07967 5g Ask for price

Fmoc-Thr-Wang resin

5-07968 25g Ask for price

Fmoc-Trp-Wang resin

5-07975 5g Ask for price

Fmoc-Trp-Wang resin

5-07976 25g Ask for price

Fmoc-Val-Wang resin

5-07989 5g Ask for price

Fmoc-Val-Wang resin

5-07990 25g Ask for price

2-Chlorotrityl Chloride Resin

5-08183 25g Ask for price

2-Chlorotrityl Chloride Resin

5-08184 100g Ask for price

2-Chlorotrityl Chloride Resin

5-08185 25g Ask for price

2-Chlorotrityl Chloride Resin

5-08186 100g Ask for price

Fmoc-Leu-Tcp Resin

5-08289 5g Ask for price

Fmoc-Leu-Tcp Resin

5-08290 25g Ask for price

Protein A-Agarose Resin

55000 1 mL
EUR 132
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200

Protein A-Agarose Resin

55005 5 mL
EUR 306
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200

Protein L Agarose Resin

4BCLPL-10 10 ml
EUR 393

Protein L Agarose Resin

4BCLPL-2 2 ml
EUR 197

Protein L Agarose Resin

4BCLPL-5 5 ml
EUR 284

Fmoc-Gly-Wang resin

20-abx095122
  • EUR 551.00
  • EUR 258.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

MP-Sulfonic acid resin

20-abx095135
  • EUR 439.00
  • EUR 230.00
  • 100 g
  • 25 g
  • Shipped within 5-10 working days.

2-Chlorotrityl Chloride resin

20-abx095137
  • EUR 467.00
  • EUR 899.00
  • EUR 230.00
  • EUR 1609.00
  • 100 g
  • 250 g
  • 25 g
  • 500 g
  • Shipped within 5-10 working days.

Rink Amide AM resin

20-abx095146
  • EUR 801.00
  • EUR 4156.00
  • EUR 1455.00
  • EUR 328.00
  • EUR 2249.00
  • 100 g
  • 1 kg
  • 250 g
  • 25 g
  • 500 g
  • Shipped within 5-10 working days.

Rink Amide-AM Resin

A6780-100000 100 g
EUR 727
Description: Rink Amide-AM Resin

Rink Amide-AM Resin

A6780-25000 25 g
EUR 389
Description: Rink Amide-AM Resin

Rink Amide-AM Resin

A6780-5000 5 g
EUR 219
Description: Rink Amide-AM Resin

2-Chlorotrityl Chloride Resin

A6791-100000 100 g
EUR 328
Description: 2-Chlorotrityl Chloride Resin

2-Chlorotrityl Chloride Resin

A6791-25000 25 g
EUR 142
Description: 2-Chlorotrityl Chloride Resin

Fmoc-Phe-Wang resin

A6831-25000 25 g
EUR 205
Description: Fmoc-Phe-Wang resin

Fmoc-Phe-Wang resin

A6831-5000 5 g
EUR 87
Description: Fmoc-Phe-Wang resin

Fmoc-Ile-Wang resin

A6836-25000 25 g
EUR 205
Description: Fmoc-Ile-Wang resin

Fmoc-Ile-Wang resin

A6836-5000 5 g
EUR 87
Description: Fmoc-Ile-Wang resin

Fmoc-Gly-Wang resin

A6839-25000 25 g
EUR 205
Description: Fmoc-Gly-Wang resin

Fmoc-Gly-Wang resin

A6839-5000 5 g
EUR 87
Description: Fmoc-Gly-Wang resin

Protein A Agarose Resin

PA09-100 100 ml
EUR 2094

Protein A Agarose Resin

PA09-25 25 ml
EUR 925

Protein A Agarose Resin

PA09-5 5 ml
EUR 291

Streptavidin 6HC Agarose Resin

STV6HC-10 10 ml
EUR 399

Streptavidin 6HC Agarose Resin

STV6HC-20 20 ml
EUR 685

Streptavidin 6HC Agarose Resin

STV6HC-5 5 ml
EUR 237

Protein A Agarose Resin

BSP095-7 1ml
EUR 93.5
  • Product category: Biochemicals/Biology Reagents/Protein Related

Protein A Agarose Resin

BSP095-8 5ml
EUR 245.75
  • Product category: Biochemicals/Biology Reagents/Protein Related

Protein A Sefinose Resin

BSP096-25 12.5ml
EUR 702.5
  • Product category: Biochemicals/Biology Reagents/Protein Related

Protein A Sefinose Resin

BSP096-5 2.5ml
EUR 193.55
  • Product category: Biochemicals/Biology Reagents/Protein Related

Protein G Agarose Resin

SF022-PG 5ml
EUR 775
  • Product category: Biochemicals/Biology Reagents/Protein Related

c6010 kit epoxy ph/ec/tds/sal/res

C6010PKE ea
EUR 766

c6030 kit epoxy ph/ec/tds/sal/res

C6030PKE ea
EUR 1003

c3010 kit epoxy ph/ec/tds/sal/res

C3010PKE ea
EUR 849

c3030 kit epoxy ph/ec/tds/sal/res

C3030PKE ea
EUR 1136

Absolute Mag Epoxy Silica Magnetic Particles, 1.5 µm

SMP-UM05 500 mg
EUR 814

Absolute Mag Epoxy Silica Magnetic Particles, 6 µm

SMP-UM18 500 mg
EUR 720

2-Carboxymethyl-3-preny-2,3-epoxy-1,4-naphthoquinone

TBZ0135 unit Ask for price

Absolute Mag Epoxy Magnetic Particles, 0.5-1.0 μm

WHM-Q075 10 mL
EUR 559

Absolute Mag Epoxy Magnetic Particles, 1.0-2.0 μm

WHM-Q076 10 mL
EUR 559

Absolute Mag Epoxy Magnetic Particles, 2.0-3.0 μm

WHM-Q077 10 mL
EUR 559

Conclusion: Work-related respiratory symptoms are common among dentists and indicate efforts to establish effective programs and techniques for reducing or eliminating direct exposure to chemicals in the air in the dental environment.

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