Checklist and provisional atlas of singing cicadas (Hemiptera: Cicadidae) of Bulgaria, based on bioacoustics

Background: The Cicadas Singers (hemiptera: cigadidae) of Bulgaria were poorly known. There are records published for 14 species: Cicada Orni, Lyrists Plebejus, Cicadatra Atra, Cicadatra Hyalina, Cicadatra Persica, Cicadatta Persica, Cicadetta Montana, Cicadetta Mediterranea, Timissaleta Dimissa, Oliglena Tibialis, Tympanistalis Gastrica, Pagiphora Annulata, Saiticula Coriaria, Tibicina Haematodes and Tibicina Steveni.

New information: Two species of this list were doubtful at the beginning of our study, because Tympanistalna Gastrica is distributed in the center and southern Portugal and Saiala Coriaria is a North African species. We have verified three main institutional collections hosted in Sofia, Bulgaria: the National Museum of Natural History (SOFM), the Institute of Zoology (ZISB) and the Faculty of Biology at Sofia University “St. Kliment ohridski »(BFU). We have confirmed 11 species mentioned in the literature, with the exception of Cicadetta Mediterranea and found two additional species: Cicadata Plassyptera and Cicadetta Macedonica (BFU specimens were confirmed bioacoustically).

Based on this knowledge, we still studied the Bulgaria’s singing cicadas with the use of morphological and bioacoustic methods in the years 2008, 2009, 2010, 2012, 2012, 2016 and 2019. We could not confirm the presence of Cicadata Persica and Cicadetta Mediterranea, but has Found three additional species: Cicadetta BreviNnis s. Lat., Cicadetta Cantilatrix and Tettettula Pygmea. Using bioacoustic methods, we also detected unknown song models, which could belong to three or four additional taxa, which must be described. The Bulgarian fauna of Cicada singing at the same time is composed of 16 potential species confirmed and 3-4.

 

SCN1A mutation spectrum in a cohort of Bulgarian patients at the GEFS + phenotype

BACKGROUND: Dravet syndrome (DS) is the most serious form of widespread epilepsy with febrile crisis syndrome and febrile supports (GEFS +) with a clear genetic component in 85% of cases. It is characterized by a seizure caused by fever of about six months and a deterioration of subsequent development later in life.

Methods: In the current study, 60 patients with crises and suspicions caused by fever, either FEMS + (50 patients) or DS (10 patients) were referred for the analysis of the SCN1A genes sequence.

Results: SCN1A Gene Sequencing revealed clinically significant variants in 11 patients (18.3%); Seven pathogens (11.7%) and four probable pathogens (6.7%). Five of these variants were not reported previously. Among the preselected group of ten DS patients, five had SCN1A pathogenic variants that confirmed the diagnosis of DS. In four patients with preliminary diagnosis GEFS +, the detected variant SCN1A allowed us to specify the diagnosis of DS in these patients. Thus, the SCN1A sequencing resulted in a confirmation of the 50% (5/10) genetic diagnosis of DS patients, as well as to clarify the diagnosis of DS in 8% of FEMS + patients (450). In this study, four patients with truncating mutations have had refractory crises and additional psychomotor anomalies. In addition, Missense pathogenic mutations have been detected in three children with comparable phenotypes, which favors observations that mutations despite critical channel function regions can cause a devastating epileptic disease.

Conclusions: This is the first systematic screening of the SCN1A gene in our country, which expands the spectrum of SCN1A variants with five new variants in Bulgaria and demonstrates the clinical utility of CNN1A confirmatory tests, which helps clinicians make Early and precise diagnoses. It is important for better monitoring, the choice of appropriate treatment, the prevention of the development of refractory seizures and neuropsychological complications. Identification of pathogenic variants in the SCN1A in the milder cases of FEMS + and serious DS, will help provide adequate prenatal diagnosis and improve genetic tips for affected families.

 Checklist and provisional atlas of singing cicadas (Hemiptera: Cicadidae) of Bulgaria, based on bioacoustics
Checklist and provisional atlas of singing cicadas (Hemiptera: Cicadidae) of Bulgaria, based on bioacoustics

Respiratory symptoms of exposure to workplace substances among Bulgarian dentists

Objectives: Dentists are exposed to a variety of airborne chemicals that can serve as irritants and sensitizers and can give rise to work-related respiratory symptoms. The objective of this study was to estimate the prevalence of respiratory symptoms of exposure to workplace substances and risk factors involved in Bulgarian dentists.

Methods: A cross-sectional study was conducted among Bulgarian dentists using a self-recall questionnaire. A direct acyclic chart (DAG) has been developed to illustrate direct and indirect causal paths between exposure to irritants and / or allergens from the dental environment and work-related respiratory symptoms in dentists. A multiple logistic regression analysis was performed to study the relationship between sex, work experience, daily exposure to chemicals from the dental environment, a history of atopic disorders and respiratory symptoms related to the job.

Results: A total of 4675 dentists completed the questionnaire (response rate 48.1%). The prevalence of self-reported respiratory symptoms was 20.7%. The most commonly repeated causes of respiratory reactions were disinfectants (65.7%) and materials based on acrylic resins (29.7%). Factors associated with work-related respiratory symptoms are a personal history of confidence interval of asthma, work experience> 20 years and female sex.

 

Phenolic acid

HY-125909 Get quote Ask for price
Description: Phenolic acid is an endogenous metabolite.

Phenolic VH101

533724 50.0mg
EUR 950

Phenolic auramine

S042-125ML 1 unit
EUR 18.02
Description: Phenolic auramine

Phenolic auramine

S042-500ML 1 unit
EUR 62.85
Description: Phenolic auramine

Phenolic auramine O

S042Y-125ML 1 unit
EUR 18.22
Description: Phenolic auramine O

Phenolic auramine O

S042Y-1L 1 unit
EUR 113.84
Description: Phenolic auramine O

Phenolic auramine O

S042Y-500ML 1 unit
EUR 63.73
Description: Phenolic auramine O

Phenolic Beads, Hollow

17806-100 100g
EUR 264

Salsalate Phenolic Glucuronide

S095710 100mg
EUR 1800

Salicylic acid phenolic D-glucuronide

GC2631 5mg
EUR 1570.47

Salicylic acid phenolic D-glucuronide

GC2631-10 10
EUR 624.6

Salicylic acid phenolic D-glucuronide

GC2631-25 25
EUR 1099.9

Salicylic acid phenolic D-glucuronide

GC2631-5 5
EUR 372.8

Salicylic acid phenolic D-glucuronide

GC2631-50 50
EUR 1715.2

Phenolic GPI 15-415 Screw Cap - PK288

TIS1558 PK288
EUR 363.15

Avenanthramide A Phenolic Glucuronide 1

A398540 100mg
EUR 3000

Avenanthramide A Phenolic Glucuronide 2

A398550 100mg
EUR 9200

Phenolic Compounds Assay Kit (Colorimetric)

K527-200 each
EUR 660

Mycophenolic acid phenolic b-D-glucoside

GC3274 1mg
EUR 1433.83

Mycophenolic acid phenolic b-D-glucoside

GC3274-1 1
EUR 289

Mycophenolic acid phenolic b-D-glucoside

GC3274-10 10
EUR 1566

Mycophenolic acid phenolic b-D-glucoside

GC3274-2 2
EUR 466.1

Mycophenolic acid phenolic b-D-glucoside

GC3274-5 5
EUR 913.6

Mycophenolic Acid Phenolic b-D-Glucoside

M831530 1mg
EUR 1052
Description: 55533-52-3

DURAN Over-Cap 45mm Black Phenolic - PK10

BOT2596 PK10
EUR 33.75

Mycophenolic Acid Phenolic beta-D-Glucoside

MBS6115983-1mg 1(mg
EUR 580

Mycophenolic Acid Phenolic beta-D-Glucoside

MBS6115983-5x1mg 5x1mg
EUR 2470

75cm U-Shaped Phenolic Cap TC Flask - PK100

430725U PK100
EUR 352.35

Human Phenolic Glycolipid-1-PGL-1- ELISA Kit

QY-E05861 96T
EUR 400

Cap Phenolic GPI 18-415 Screw Cap Teflon Liner Corning - PK192

TIS1560 PK192
EUR 160.65

Recombinant Bacillus subtilis Phenolic acid decarboxylase padC (padC)

MBS1228997-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1080

Recombinant Bacillus subtilis Phenolic acid decarboxylase padC (padC)

MBS1228997-002mgEColi 0.02mg(E-Coli)
EUR 675

Recombinant Bacillus subtilis Phenolic acid decarboxylase padC (padC)

MBS1228997-002mgYeast 0.02mg(Yeast)
EUR 835

Recombinant Bacillus subtilis Phenolic acid decarboxylase padC (padC)

MBS1228997-01mgEColi 0.1mg(E-Coli)
EUR 780

Recombinant Bacillus subtilis Phenolic acid decarboxylase padC (padC)

MBS1228997-01mgYeast 0.1mg(Yeast)
EUR 975

Black Phenolic screw thread cap open top linerless autoclavable - PK144

VIA2522 PK144
EUR 67.5

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit B (bsdB)

MBS1097030-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1125

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit B (bsdB)

MBS1097030-002mgEColi 0.02mg(E-Coli)
EUR 705

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit B (bsdB)

MBS1097030-002mgYeast 0.02mg(Yeast)
EUR 875

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit B (bsdB)

MBS1097030-01mgEColi 0.1mg(E-Coli)
EUR 845

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit B (bsdB)

MBS1097030-01mgYeast 0.1mg(Yeast)
EUR 1025

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit D (bsdD)

MBS1252193-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1000

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit D (bsdD)

MBS1252193-002mgEColi 0.02mg(E-Coli)
EUR 565

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit D (bsdD)

MBS1252193-002mgYeast 0.02mg(Yeast)
EUR 750

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit D (bsdD)

MBS1252193-01mgEColi 0.1mg(E-Coli)
EUR 675

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit D (bsdD)

MBS1252193-01mgYeast 0.1mg(Yeast)
EUR 880

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit C (bsdC)

MBS1219967-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1340

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit C (bsdC)

MBS1219967-002mgEColi 0.02mg(E-Coli)
EUR 1035

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit C (bsdC)

MBS1219967-002mgYeast 0.02mg(Yeast)
EUR 1135

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit C (bsdC)

MBS1219967-01mgEColi 0.1mg(E-Coli)
EUR 1210

Recombinant Bacillus subtilis Phenolic acid decarboxylase subunit C (bsdC)

MBS1219967-01mgYeast 0.1mg(Yeast)
EUR 1290

D.E.R. (Dow epoxy resins), Grade 732

02922-450 450g
EUR 79
Description: 26142-30-3

D.E.R. (Dow epoxy resins), Grade 736

02923-450 450g
EUR 70
Description: 26142-30-3

CORNING® REUSABLE PHENOLIC GPI 18-415 THREADED SCREW CAP WITH RUBBER LINER

9999-182 32/pk
EUR 99.6
Description: General Apparatus; Stoppers

CORNING® REUSABLE PHENOLIC GPI 24-410 THREADED SCREW CAP WITH RUBBER LINER

9999-241 36/pk
EUR 118.8
Description: General Apparatus; Stoppers

CORNING® REUSABLE PHENOLIC GPI 28-400 THREADED SCREW CAP WITH RUBBER LINER

9999-28 144/pk
EUR 288
Description: General Apparatus; Stoppers

CORNING® REUSABLE PHENOLIC GPI 28-410 THREADED SCREW CAP WITH RUBBER LINER

9999-281 12/pk
EUR 61.2
Description: General Apparatus; Stoppers

CORNING® REUSABLE PHENOLIC GPI 38-400 THREADED SCREW CAP WITH RUBBER LINER

9999-38 36/pk
EUR 266.4
Description: General Apparatus; Stoppers

CORNING® REUSABLE PHENOLIC GPI 40-400 THREADED SCREW CAP WITH RUBBER LINER

9999-40 72/pk
EUR 168
Description: General Apparatus; Stoppers

Recombinant Vibrio cholerae serotype O1 Probable phenolic acid decarboxylase (padC)

MBS1477410-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1095

Recombinant Vibrio cholerae serotype O1 Probable phenolic acid decarboxylase (padC)

MBS1477410-002mgEColi 0.02mg(E-Coli)
EUR 690

Recombinant Vibrio cholerae serotype O1 Probable phenolic acid decarboxylase (padC)

MBS1477410-002mgYeast 0.02mg(Yeast)
EUR 850

Recombinant Vibrio cholerae serotype O1 Probable phenolic acid decarboxylase (padC)

MBS1477410-01mgEColi 0.1mg(E-Coli)
EUR 800

Recombinant Vibrio cholerae serotype O1 Probable phenolic acid decarboxylase (padC)

MBS1477410-01mgYeast 0.1mg(Yeast)
EUR 990

Araldite resins (modified epoxy resins), Grade 6005

02116-500 500g
EUR 57
Description: 3101-60-8

Reusable Phenolic GPI 13-415 Threaded Screw Cap with Teflon Liner Corning - PK288

TIS1556 PK288
EUR 361.8

Disposable Phenolic GPI 13-415 Threaded Screw Cap with Rubber Liners Corning - PK1000

TIS1550 PK1000
EUR 392.85

Disposable Phenolic GPI 18-415 Threaded Screw Cap with Rubber Liners Corning - PK1000

TIS1554 PK1000
EUR 549.45

Corning 175cm2 Rectangular Angled Neck Cell Culture Flask with Phenolic-Style Cap - PK50

431085 PK50
EUR 427.95

Corning 25cm2 Rectangular Canted Neck Cell Culture Flask with Phenolic-Style Cap - PK500

430372 PK500
EUR 839.7

Mycophenolic Acid Methyl Ester Phenolic 6-(2,3,4,6-tetra-O-Acetyl-beta-D-glucoside)

MBS6113021-5mg 5(mg
EUR 610

Mycophenolic Acid Methyl Ester Phenolic 6-(2,3,4,6-tetra-O-Acetyl-beta-D-glucoside)

MBS6113021-5x5mg 5x5(mg
EUR 2600

Phenolics Mix - 1ML

CLPS-A 1ML
EUR 59.4

Phenolics Mix A - 1ML

CLPS-AI 1ML
EUR 126.9

Phenolics Mix B - 1ML

8040-B 1ML
EUR 83.7

Capto Phenyl ImpRes resin

Ca-419C 25 mL
EUR 472
Description: Chromatography Reagents

Capto Phenyl (High Sub) resin

Ca-418C 25 mL
EUR 456
Description: Chromatography Reagents

Epon® Resin 1001F

24305-500 500g
EUR 103
Description: 25036-25-3

Epoxy Metradiene

E589245 10mg
EUR 224
Description: 83873-16-9

Epon® Resin 828

02334-500 500g
EUR 146
Description: 25068-38-6

Epoxy Costuslactone

TBW00951 20mg Ask for price

3,4-Epoxy-6-methylcyclohexylmethyl-3,4-epoxy-6-methylcyclohexanecarboxylate

E01425 1G
EUR 132.83

DiagSupport™ 4-(Hydroxymethyl)phenoxyaceamidomethyl Polystyrene/DVB Resin, 100-200 Mesh, 0.3-0.8 mmol/g

SPS-AP23-153 5 g
EUR 660

MagSi-S Epoxy 600

MD16010 2 mL
EUR 153.6

MagSi-S Epoxy 600

MD18010 10 mL
EUR 572.4

MagSi-S Epoxy 600

MD19010 100 mL
EUR 3438

1,2-Epoxy GA3

E589425 10mg
EUR 2185
Description: 147918-01-2

4-(2',4'-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxymethyl-polystyrene resin (200-400 mesh, 0.80-1.20 mmol/g)

4026912.0001 1 g
EUR 75.29

4-(2',4'-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxymethyl-polystyrene resin (200-400 mesh, 0.80-1.20 mmol/g)

4026912.0005 5 g
EUR 280.88

4-(2',4'-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxymethyl-polystyrene resin (200-400 mesh, 0.80-1.20 mmol/g)

4026912.0025 25 g
EUR 1104.39

4-(2',4'-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxymethyl-polystyrene resin (200-400 mesh, 0.80-1.20 mmol/g)

D-2080.0001 1.0g
EUR 151.2

4-(2',4'-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxymethyl-polystyrene resin (200-400 mesh, 0.80-1.20 mmol/g)

D-2080.0005 5.0g
EUR 471.6

4-(2',4'-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxymethyl-polystyrene resin (200-400 mesh, 0.80-1.20 mmol/g)

D-2080.0025 25.0g
EUR 1748.4

Epoxy Fluor 7

HY-121941 1mg
EUR 101.73
Description: Epoxy Fluor 7 is a sensitive fluorescent substrate for soluble epoxide hydrolase (sEH) that can be used for human and mouse enzymes. Epoxy Fluor 7 is hydrolyzed to yield fluorescence used for monitoring the activity of sEH.

c3010 kit epoxy ec/tds/sal/res

C3010KE ea
EUR 910.8

c3030 kit epoxy ec/tds/sal/res

C3030KE ea
EUR 1256.4

c6030 kit epoxy ec/tds/sal/res

C6030KE ea
EUR 1095.6

C3210 KIT EPOXY EC/TDS/SAL/RES

C3210KE each
EUR 1168

C3230 KIT EPOXY EC/TDS/SAL/RES

C3230KE each
EUR 1378

1,2-Epoxy-9-decene

E589298 2.5g
EUR 75
Description: 85721-25-1

1,2-Epoxy-7-octene

E589940 1g
EUR 138
Description: 19600-63-6

3,4-Epoxy-moxidectin

E589045 10mg
EUR 913
Description: 1402163-94-3

3,4-Epoxy-2-pentanone

E589735 100mg
EUR 402
Description: 17257-79-3

c3010 kit epoxy ph/ec/tds/sal/res

C3010PKE ea
EUR 1018.8

c3030 kit epoxy ph/ec/tds/sal/res

C3030PKE ea
EUR 1363.2

c6010 kit epoxy ph/ec/tds/sal/res

C6010PKE ea
EUR 919.2

c6030 kit epoxy ph/ec/tds/sal/res

C6030PKE ea
EUR 1203.6

C3210 KIT EPOXY PH/EC/TDS/SAL/RES

C3210PKE each
EUR 1322

C3230 KIT EPOXY PH/EC/TDS/SAL/RES

C3230PKE each
EUR 1532

16,17-Epoxy-21-acetoxypregnenolone

T3225-10mg 10mg Ask for price
Description: 16,17-Epoxy-21-acetoxypregnenolone

16,17-Epoxy-21-acetoxypregnenolone

T3225-1g 1g Ask for price
Description: 16,17-Epoxy-21-acetoxypregnenolone

16,17-Epoxy-21-acetoxypregnenolone

T3225-1mg 1mg Ask for price
Description: 16,17-Epoxy-21-acetoxypregnenolone

16,17-Epoxy-21-acetoxypregnenolone

T3225-50mg 50mg Ask for price
Description: 16,17-Epoxy-21-acetoxypregnenolone

16,17-Epoxy-21-acetoxypregnenolone

T3225-5mg 5mg Ask for price
Description: 16,17-Epoxy-21-acetoxypregnenolone

16,17-Epoxy-21-acetoxypregnenolone

MBS3608356-100mg 100mg
EUR 250

16,17-Epoxy-21-acetoxypregnenolone

MBS3608356-200mg 200mg
EUR 320

16,17-Epoxy-21-acetoxypregnenolone

MBS3608356-25mg 25mg
EUR 200

16,17-Epoxy-21-acetoxypregnenolone

MBS3608356-50mg 50mg
EUR 215

16,17-Epoxy-21-acetoxypregnenolone

MBS3608356-5x200mg 5x200mg
EUR 1105

c3010 kit epoxy ph

C3010PE ea
EUR 895.2

c3030 kit epoxy ph

C3030PE ea
EUR 1239.6

c6010 kit epoxy ec

C6010KE ea
EUR 812.4

c6010 kit epoxy ph

C6010PE ea
EUR 795.6

c6030 kit epoxy ph

C6030PE ea
EUR 1080

MagSi-S Epoxy 1.0

MD01010 2 mL
EUR 139.2

MagSi-S Epoxy 1.0

MD03010 10 mL
EUR 483.6

MagSi-S Epoxy 1.0

MD04010 100 mL
EUR 2898

MagSi-S Epoxy 3.0

MD41010 2 mL
EUR 139.2

MagSi-S Epoxy 3.0

MD43010 10 mL
EUR 483.6

MagSi-S Epoxy 3.0

MD44010 100 mL
EUR 2898

C3210 KIT EPOXY PH

C3210PE each
EUR 1184

C3230 KIT EPOXY PH

C3230PE each
EUR 1394

1,2-Epoxy-4-vinylcyclohexane

E01540 5ML
EUR 74.54

7,8-Epoxy-vitamin D3

E892195 10mg
EUR 1275
Description: 89231-90-3

R-3,4-Epoxy-1-butanol

E589786 500mg
EUR 1800
Description: 76282-48-9

c3010 kit epoxy ph/ec/tds/sal/res/o2

C3010TE ea
EUR 1267.2

c3030 kit epoxy ph/ec/tds/sal/res/o2

C3030TE ea
EUR 1611.6

c6010 kit epoxy ph/ec/tds/sal/res/o2

C6010TE ea
EUR 1167.6

c6030 kit epoxy ph/ec/tds/sal/res/o2

C6030TE ea
EUR 1452

C3210 KIT EPOXY PH/EC/TDS/SAL/RES/O2

C3210TE each
EUR 1602

C3230 KIT EPOXY PH/EC/TDS/SAL/RES/O2

C3230TE each
EUR 1812

c3050 kit epoxy ph/ec/sal/tds/res/orp

C3050TE ea
EUR 1935.6

1,2-α-Epoxy Exemestane

E589340 50mg
EUR 800
Description: 159354-61-7

8,9-Epoxy-moxidectin (>90%)

E589248 1mg
EUR 2151

5α,6α-epoxy Cholestanol

T35973-10mg 10mg Ask for price
Description: 5α,6α-epoxy Cholestanol

5α,6α-epoxy Cholestanol

T35973-1g 1g Ask for price
Description: 5α,6α-epoxy Cholestanol

5α,6α-epoxy Cholestanol

T35973-1mg 1mg Ask for price
Description: 5α,6α-epoxy Cholestanol

Conclusion: Work-related respiratory symptoms are common among dentists and indicate efforts to establish effective programs and techniques for reducing or eliminating direct exposure to chemicals in the air in the dental environment.

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