Altered electroencephalographic networks in developmental dyslexia after remedial training: a prospective case-control study

Electroencephalographic studies using a graphical theoretical analysis found aberrations in functional connectivity in children with development dyslexia. However, how training with visual tasks can change the functional connectivity of the Semantic Dyslexia Development Network is still unclear. We have sought differences in local and global topological properties of functional networks between 21 healthy controls and 22 dyslexic children (8-9 years old) before and after training with visual tasks in this prospective case study. The expanded minimum tree method was used to build the brain networks of subjects in several electroencephalographic frequency ranges during a visual task of Word / Pseudoword discrimination.

We found group differences in the Theta, Alpha, Beta and Gamma bands for four graphical measurements suggesting a more integrated network topology in the dyslexic before training compared to controls. After training, the topology of the network of dyslexic children had become more separated and similar to that of controls. In the strips θ, α and β1-frequencies, compared to the controls, the pre-coaching dyslexics presented a reduced degree and a centrality between the anterior left and parietal temporal regions. The simultaneous appearance in the left hemisphere of temporal and parietal cortex concentries (α, β1), temporal and upper (θ, α), parietal and ocipitotemporal corretips (β1), identified in the normally developing children’s networks n ‘was not present in the cerebral networks of the dyslexic.

 

After training, the Hub distribution for dyslexic in the Theta and Beta1 bands had become similar to that of controls. In summary, our results indicate a less effective network configuration in the dyslexus compared to a more optimal world organization of controls. This is the first study to study the topological organization of functional brain networks of Bulgarian dyslexic children. The approval of the study was obtained from the Ethics Committee of the Institute of Neurobiology and the Institute of Population and Human Studies.

 

Thermostable enzymes and polysaccharides produced by thermophilic bacteria isolated from Bulgarian hot springs

Thermozatable enzymes (thermozymes) have been recognized as compounds extremely extremely important biotechnology in different industrial zones. Recently, exopolysaccharides (EPSS) synthesized by thermophiles have become an object of increasing the interest of the research because of their unique properties adapted to certain specific industrial needs. The thermophilic producers of biotechnologically valuable enzymes and new EPS have been isolated by our group of Bulgarian thermal springs with a diverse geotectonic origin and different properties of water.

Laboratory reactor processes for their production have been developed in batch and continuous crops. Some of the synthesized thermostable enzymes were among the first described in their groups, for example, the known single thermostable gellan lyase that demonstrated a specific activity superior to that of mesophilic enzymes. Isolated by US Thermostable Xylanase was able to degrade more than 60% Beechwood Xylan in a coprocess with an archae β-xylosidase. The lipase purified by us was active between 55 and 90 ° C with an optimum at 75-80 ° C in a large pH range. It was able to degrade a wide range of substrates. Isans Bulgarian warm sources synthesized EPS with a new composition and high thermostability. Thus, Bulgarian hot springs are a wide range of thermophilic producers of new enzymes and EPA with a large number of biotechnology applications.

Potential of the enzymatic ligninolytic complex produced by mushrooms of white rot from isolated genus of the Bulgarian forest floor

Due to the crucial role of ligninolytic enzymes in a variety of industrial processes, the demand for a new effective producer has consistently increased. In addition, information on the synthesis of the enzyme by autochatonous fungus strains are very rarely found. Two fungal strains producing ligninolytic enzymes have been isolated from Bulgarian Forest Floor. They have been identified as trogii and T. hirsuta trameters. These two strains were evaluated for their enzymatic activities, laccase (lake), lignin peroxidase (LIP) and peroxidase (MNP) dependent on the culture filtrate according to the temperature and type of nutrient medium. T. trogii has been selected as a better producer of ligninolytic enzymes. The production process has also been improved by optimizing a number of parameters such as incubation time, the type of cultivation, the average volume ratio / air, inoculum size and the addition of inducers .

The maximum enzyme activities synthesized by T. trogii were detected as 11100 U / L for tray, 2.5 U / L for lip and 4.5 U / L for MNP after 14 days of incubation at 25 ° C under conditions Static, average volume ratio / air 1: 6 and 3 plugs as inoculum. Among the supplements tested, 5% glycerol increases the activity of the gap to a large extent. The addition of 1% VERATRLER alcohol had a positive effect on the MNP. Traditional fermented dairy products have been prepared since the ancient period by various civilizations. Despite their long history, their popularity and nutrient and healthy value, the acceleration and industrialization of food production lead to an increase in the diversity of fermented dairy products in the Balkan peninsula.

Aminomethyl Polystyrene Resin
5-08193	CHI Scientific	25g	Ask for price

Aminomethyl Polystyrene Resin
5-08194	CHI Scientific	100g	Ask for price

Glutathione Agarose Resin
4B-GLU-10	ABTBeads	10 ml	EUR 207.6

Glutathione Agarose Resin
4B-GLU-100	ABTBeads	100 ml	EUR 1195.2

Biotin Agarose Resin
4BCL-BI-10	ABTBeads	10 ml	EUR 493.2

Biotin Agarose Resin
4BCL-BI-5	ABTBeads	5 ml	EUR 282

MP-EDC resin
20-abx095129	Abbexa	EUR 1262.40 EUR 526.80 EUR 260.40	100 g 25 g 5 g

MP-TEMPO resin
20-abx095130	Abbexa	EUR 1262.40 EUR 526.80 EUR 260.40	100 g 25 g 5 g

MP-Aminomethyl resin
20-abx095132	Abbexa	EUR 393.60 EUR 226.80	100 g 25 g

MP-Acetylacetone resin
20-abx095133	Abbexa	EUR 526.80 EUR 276.00	100 g 25 g

MP-Piperazinomethyl resin
20-abx095134	Abbexa	EUR 526.80 EUR 276.00	100 g 25 g

MP-Diethylenetriamine resin
20-abx095136	Abbexa	EUR 543.60 EUR 276.00	100 g 25 g

MP-Carbonate resin
20-abx095138	Abbexa	EUR 560.40 EUR 292.80	100 g 25 g

MP-Morpholinomethyl resin
20-abx095139	Abbexa	EUR 560.40 EUR 292.80	100 g 25 g

MP-Thiosulfate resin
20-abx095140	Abbexa	EUR 560.40 EUR 292.80	100 g 25 g

MP-Mercaptomethyl resin
abx095141-100g	Abbexa	100 g	EUR 610.8

MP-TMT resin
20-abx095142	Abbexa	EUR 693.60 EUR 326.40	100 g 25 g

Ni-NTA Resin
20-abx098108	Abbexa	EUR 610.80 EUR 292.80	25 ml 5 ml

Ni-IDA Resin
20-abx098109	Abbexa	EUR 543.60 EUR 276.00	25 ml 5 ml

Protein A Resin
abx098111-5ml	Abbexa	5 ml	EUR 477.6

Protein G Resin
abx098112-5ml	Abbexa	5 ml	EUR 526.8

DHP HM Resin
A6789-100000	ApexBio	100 g	EUR 616.8
Description: DHP HM Resin

DHP HM Resin
A6789-25000	ApexBio	25 g	EUR 243.6
Description: DHP HM Resin

Rink Amide Resin
A6576-100000	ApexBio	100 g	EUR 1136.4
Description: Rink resin is originally developed for SPS of peptide amides. Now the scope of its application is extended from carboxylic amides to the immobilization of amines, substituted amides.

Rink Amide Resin
A6576-25000	ApexBio	25 g	EUR 358.8
Description: Rink resin is originally developed for SPS of peptide amides. Now the scope of its application is extended from carboxylic amides to the immobilization of amines, substituted amides.

GST-Sefinose Resin
BSP031	Bio Basic	5ml	EUR 174.84

GST-Sefinose Resin
BSP031-1	Bio Basic	25ml	EUR 498.48

Nickel NTA Agarose Resin
6BCL-NTANi-100	ABTBeads	100 ml	EUR 781.2

Nickel NTA Agarose Resin
6BCL-NTANi-25	ABTBeads	25 ml	EUR 260.4

Nickel NTA Agarose Resin
6BCL-NTANi-500	ABTBeads	500 ml	EUR 3100.8

Protein A-Agarose Resin
55000	AAT Bioquest	1 mL	EUR 158.4

Protein A-Agarose Resin
55005	AAT Bioquest	5 mL	EUR 367.2

Fmoc-Ala-Wang resin
5-07835	CHI Scientific	5g	Ask for price

Fmoc-Ala-Wang resin
5-07836	CHI Scientific	25g	Ask for price

Fmoc-Acp-Wang resin
5-07841	CHI Scientific	5g	Ask for price

Fmoc-Acp-Wang resin
5-07842	CHI Scientific	25g	Ask for price

Fmoc-Cha-Wang Resin
5-07863	CHI Scientific	5g	Ask for price

Fmoc-Cha-Wang Resin
5-07864	CHI Scientific	25g	Ask for price

Fmoc-Cit-Wang resin
5-07867	CHI Scientific	5g	Ask for price

Fmoc-Cit-Wang resin
5-07868	CHI Scientific	25g	Ask for price

Fmoc-Gly-Wang resin
5-07891	CHI Scientific	5g	Ask for price

Fmoc-Gly-Wang resin
5-07892	CHI Scientific	25g	Ask for price

Fmoc-Gly-Wang resin
5-07893	CHI Scientific	5g	Ask for price

Fmoc-Gly-Wang resin
5-07894	CHI Scientific	25g	Ask for price

Fmoc-Ile-Wang resin
5-07899	CHI Scientific	5g	Ask for price

Fmoc-Ile-Wang resin
5-07900	CHI Scientific	25g	Ask for price

Fmoc-Leu-Wang resin
5-07903	CHI Scientific	5g	Ask for price

Fmoc-Leu-Wang resin
5-07904	CHI Scientific	25g	Ask for price

Fmoc-Leu-Wang resin
5-07905	CHI Scientific	5g	Ask for price

Fmoc-Leu-Wang resin
5-07906	CHI Scientific	25g	Ask for price

Fmoc-Lys-Wang resin
5-07907	CHI Scientific	5g	Ask for price

Fmoc-Lys-Wang resin
5-07908	CHI Scientific	25g	Ask for price

Fmoc-Met-Wang resin
5-07923	CHI Scientific	5g	Ask for price

Fmoc-Met-Wang resin
5-07924	CHI Scientific	25g	Ask for price

Fmoc-Phe-Wang resin
5-07929	CHI Scientific	5g	Ask for price

Fmoc-Phe-Wang resin
5-07930	CHI Scientific	25g	Ask for price

Fmoc-Phe-Wang resin
5-07931	CHI Scientific	5g	Ask for price

Fmoc-Phe-Wang resin
5-07932	CHI Scientific	25g	Ask for price

Fmoc-Pro-Wang resin
5-07947	CHI Scientific	5g	Ask for price

Fmoc-Pro-Wang resin
5-07948	CHI Scientific	25g	Ask for price

Fmoc-Pro-Wang resin
5-07949	CHI Scientific	5g	Ask for price

Fmoc-Pro-Wang resin
5-07950	CHI Scientific	25g	Ask for price

Fmoc-Tle-Wang Resin
5-07965	CHI Scientific	5g	Ask for price

Fmoc-Tle-Wang Resin
5-07966	CHI Scientific	25g	Ask for price

Fmoc-Thr-Wang resin
5-07967	CHI Scientific	5g	Ask for price

Fmoc-Thr-Wang resin
5-07968	CHI Scientific	25g	Ask for price

Fmoc-Trp-Wang resin
5-07975	CHI Scientific	5g	Ask for price

Fmoc-Trp-Wang resin
5-07976	CHI Scientific	25g	Ask for price

Fmoc-Val-Wang resin
5-07989	CHI Scientific	5g	Ask for price

Fmoc-Val-Wang resin
5-07990	CHI Scientific	25g	Ask for price

2-Chlorotrityl Chloride Resin
5-08183	CHI Scientific	25g	Ask for price

2-Chlorotrityl Chloride Resin
5-08184	CHI Scientific	100g	Ask for price

2-Chlorotrityl Chloride Resin
5-08185	CHI Scientific	25g	Ask for price

2-Chlorotrityl Chloride Resin
5-08186	CHI Scientific	100g	Ask for price

Fmoc-Leu-Tcp Resin
5-08289	CHI Scientific	5g	Ask for price

Fmoc-Leu-Tcp Resin
5-08290	CHI Scientific	25g	Ask for price

Protein L Agarose Resin
4BCLPL-10	ABTBeads	10 ml	EUR 471.6

Protein L Agarose Resin
4BCLPL-2	ABTBeads	2 ml	EUR 236.4

Protein L Agarose Resin
4BCLPL-5	ABTBeads	5 ml	EUR 340.8

Fmoc-Gly-Wang resin
20-abx095122	Abbexa	EUR 661.20 EUR 309.60	100 g 25 g

MP-Sulfonic acid resin
20-abx095135	Abbexa	EUR 526.80 EUR 276.00	100 g 25 g

2-Chlorotrityl Chloride resin
20-abx095137	Abbexa	EUR 560.40 EUR 1078.80 EUR 276.00 EUR 1930.80	100 g 250 g 25 g 500 g

Rink Amide AM resin
20-abx095146	Abbexa	EUR 961.20 EUR 4987.20 EUR 1746.00 EUR 393.60 EUR 2698.80	100 g 1 kg 250 g 25 g 500 g

Fmoc-Phe-Wang resin
A6831-25000	ApexBio	25 g	EUR 246
Description: Fmoc-Phe-Wang resin

Fmoc-Phe-Wang resin
A6831-5000	ApexBio	5 g	EUR 104.4
Description: Fmoc-Phe-Wang resin

Fmoc-Ile-Wang resin
A6836-25000	ApexBio	25 g	EUR 246
Description: Fmoc-Ile-Wang resin

Fmoc-Ile-Wang resin
A6836-5000	ApexBio	5 g	EUR 104.4
Description: Fmoc-Ile-Wang resin

Fmoc-Gly-Wang resin
A6839-25000	ApexBio	25 g	EUR 246
Description: Fmoc-Gly-Wang resin

Fmoc-Gly-Wang resin
A6839-5000	ApexBio	5 g	EUR 104.4
Description: Fmoc-Gly-Wang resin

Rink Amide-AM Resin
A6780-100000	ApexBio	100 g	EUR 872.4
Description: Rink Amide-AM Resin

Rink Amide-AM Resin
A6780-25000	ApexBio	25 g	EUR 466.8
Description: Rink Amide-AM Resin

Rink Amide-AM Resin
A6780-5000	ApexBio	5 g	EUR 262.8
Description: Rink Amide-AM Resin

2-Chlorotrityl Chloride Resin
A6791-100000	ApexBio	100 g	EUR 393.6
Description: 2-Chlorotrityl Chloride Resin

2-Chlorotrityl Chloride Resin
A6791-25000	ApexBio	25 g	EUR 170.4
Description: 2-Chlorotrityl Chloride Resin

Protein A Agarose Resin
BSP095-7	Bio Basic	1ml	EUR 112.2

Protein A Agarose Resin
BSP095-8	Bio Basic	5ml	EUR 294.9

Protein A Sefinose Resin
BSP096-25	Bio Basic	12.5ml	EUR 843

Protein A Sefinose Resin
BSP096-5	Bio Basic	2.5ml	EUR 232.26

Protein A Agarose Resin
PA09-100	ABTBeads	100 ml	EUR 2512.8

Protein A Agarose Resin
PA09-25	ABTBeads	25 ml	EUR 1110

Protein A Agarose Resin
PA09-5	ABTBeads	5 ml	EUR 349.2

Protein G Agarose Resin
SF022-PG	Bio Basic	5ml	EUR 930

Streptavidin 6HC Agarose Resin
STV6HC-10	ABTBeads	10 ml	EUR 478.8

Streptavidin 6HC Agarose Resin
STV6HC-20	ABTBeads	20 ml	EUR 822

Streptavidin 6HC Agarose Resin
STV6HC-5	ABTBeads	5 ml	EUR 284.4

MabSelect PrismA Resin - 25mL
17549801	Scientific Laboratory Supplies	EACH	EUR 2714.34

MabSelect PrismA Resin - 200mL
17549802	Scientific Laboratory Supplies	EACH	EUR 7498.92

AFS CARTRIDGE ALL RESIN
CP1ALLRES	Scientific Laboratory Supplies	EACH	EUR 500.46

Resin cartridges for XD250
WAT2102	Scientific Laboratory Supplies	PK2	EUR 314.64

Fmoc-1-Nal-Wang resin
5-07831	CHI Scientific	5g	Ask for price

Fmoc-1-Nal-Wang resin
5-07832	CHI Scientific	25g	Ask for price

Fmoc-2-Nal-Wang resin
5-07833	CHI Scientific	5g	Ask for price

Fmoc-2-Nal-Wang resin
5-07834	CHI Scientific	25g	Ask for price

Fmoc-D-Ala-Wang resin
5-07837	CHI Scientific	5g	Ask for price

Fmoc-D-Ala-Wang resin
5-07838	CHI Scientific	25g	Ask for price

Fmoc-Arg(Pbf)-Wang resin
5-07843	CHI Scientific	5g	Ask for price

Fmoc-Arg(Pbf)-Wang resin
5-07844	CHI Scientific	25g	Ask for price

Fmoc-Asn(Trt)-Wang resin
5-07847	CHI Scientific	5g	Ask for price

Fmoc-Asn(Trt)-Wang resin
5-07848	CHI Scientific	25g	Ask for price

Fmoc-Asp(OtBu)-Wang resin
5-07853	CHI Scientific	5g	Ask for price

Fmoc-Asp(OtBu)-Wang resin
5-07854	CHI Scientific	25g	Ask for price

Fmoc-Asp-OAll-Wang Resin
5-07855	CHI Scientific	5g	Ask for price

Fmoc-Asp-OAll-Wang Resin
5-07856	CHI Scientific	25g	Ask for price

Fmoc-Cys(Acm)-Wang resin
5-07869	CHI Scientific	5g	Ask for price

Fmoc-Cys(Acm)-Wang resin
5-07870	CHI Scientific	25g	Ask for price

Fmoc-Cys(Trt)-Wang resin
5-07871	CHI Scientific	5g	Ask for price

Fmoc-Cys(Trt)-Wang resin
5-07872	CHI Scientific	25g	Ask for price

Fmoc-Cys(Trt)-Wang resin
5-07873	CHI Scientific	5g	Ask for price

Fmoc-Cys(Trt)-Wang resin
5-07874	CHI Scientific	25g	Ask for price

Fmoc-Gln(Trt)-Wang resin
5-07879	CHI Scientific	5g	Ask for price

Fmoc-Gln(Trt)-Wang resin
5-07880	CHI Scientific	25g	Ask for price

Fmoc-Glu(OAll)-Wang resin
5-07883	CHI Scientific	5g	Ask for price

Following the multitude of food microbe combinations, there are thousands of different types of fermented dairy products – yogurts, yogurt type products and various types of cheeses with proven health benefits. Among these products is the domestic Bulgarian yoghurt “Kiselo Mlyako”, whose anti-aging effect has been scientifically studied at the beginning of the 20th century. The current review overwrites the wide range of traditional fermented dairy products in the Balkan countries, which are the main source of their production.