Altered electroencephalographic networks in developmental dyslexia after remedial training: a prospective case-control study

Electroencephalographic studies using a graphical theoretical analysis found aberrations in functional connectivity in children with development dyslexia. However, how training with visual tasks can change the functional connectivity of the Semantic Dyslexia Development Network is still unclear. We have sought differences in local and global topological properties of functional networks between 21 healthy controls and 22 dyslexic children (8-9 years old) before and after training with visual tasks in this prospective case study. The expanded minimum tree method was used to build the brain networks of subjects in several electroencephalographic frequency ranges during a visual task of Word / Pseudoword discrimination.

We found group differences in the Theta, Alpha, Beta and Gamma bands for four graphical measurements suggesting a more integrated network topology in the dyslexic before training compared to controls. After training, the topology of the network of dyslexic children had become more separated and similar to that of controls. In the strips θ, α and β1-frequencies, compared to the controls, the pre-coaching dyslexics presented a reduced degree and a centrality between the anterior left and parietal temporal regions. The simultaneous appearance in the left hemisphere of temporal and parietal cortex concentries (α, β1), temporal and upper (θ, α), parietal and ocipitotemporal corretips (β1), identified in the normally developing children’s networks n ‘was not present in the cerebral networks of the dyslexic.

 

After training, the Hub distribution for dyslexic in the Theta and Beta1 bands had become similar to that of controls. In summary, our results indicate a less effective network configuration in the dyslexus compared to a more optimal world organization of controls. This is the first study to study the topological organization of functional brain networks of Bulgarian dyslexic children. The approval of the study was obtained from the Ethics Committee of the Institute of Neurobiology and the Institute of Population and Human Studies.

 

Thermostable enzymes and polysaccharides produced by thermophilic bacteria isolated from Bulgarian hot springs

Thermozatable enzymes (thermozymes) have been recognized as compounds extremely extremely important biotechnology in different industrial zones. Recently, exopolysaccharides (EPSS) synthesized by thermophiles have become an object of increasing the interest of the research because of their unique properties adapted to certain specific industrial needs. The thermophilic producers of biotechnologically valuable enzymes and new EPS have been isolated by our group of Bulgarian thermal springs with a diverse geotectonic origin and different properties of water.

Laboratory reactor processes for their production have been developed in batch and continuous crops. Some of the synthesized thermostable enzymes were among the first described in their groups, for example, the known single thermostable gellan lyase that demonstrated a specific activity superior to that of mesophilic enzymes. Isolated by US Thermostable Xylanase was able to degrade more than 60% Beechwood Xylan in a coprocess with an archae β-xylosidase. The lipase purified by us was active between 55 and 90 ° C with an optimum at 75-80 ° C in a large pH range. It was able to degrade a wide range of substrates. Isans Bulgarian warm sources synthesized EPS with a new composition and high thermostability. Thus, Bulgarian hot springs are a wide range of thermophilic producers of new enzymes and EPA with a large number of biotechnology applications.

 Altered electroencephalographic networks in developmental dyslexia after remedial training: a prospective case-control study
Altered electroencephalographic networks in developmental dyslexia after remedial training: a prospective case-control study

Potential of the enzymatic ligninolytic complex produced by mushrooms of white rot from isolated genus of the Bulgarian forest floor

Due to the crucial role of ligninolytic enzymes in a variety of industrial processes, the demand for a new effective producer has consistently increased. In addition, information on the synthesis of the enzyme by autochatonous fungus strains are very rarely found. Two fungal strains producing ligninolytic enzymes have been isolated from Bulgarian Forest Floor. They have been identified as trogii and T. hirsuta trameters. These two strains were evaluated for their enzymatic activities, laccase (lake), lignin peroxidase (LIP) and peroxidase (MNP) dependent on the culture filtrate according to the temperature and type of nutrient medium. T. trogii has been selected as a better producer of ligninolytic enzymes. The production process has also been improved by optimizing a number of parameters such as incubation time, the type of cultivation, the average volume ratio / air, inoculum size and the addition of inducers .

The maximum enzyme activities synthesized by T. trogii were detected as 11100 U / L for tray, 2.5 U / L for lip and 4.5 U / L for MNP after 14 days of incubation at 25 ° C under conditions Static, average volume ratio / air 1: 6 and 3 plugs as inoculum. Among the supplements tested, 5% glycerol increases the activity of the gap to a large extent. The addition of 1% VERATRLER alcohol had a positive effect on the MNP. Traditional fermented dairy products have been prepared since the ancient period by various civilizations. Despite their long history, their popularity and nutrient and healthy value, the acceleration and industrialization of food production lead to an increase in the diversity of fermented dairy products in the Balkan peninsula.

Wang Resin

A6776-100000 100 g
EUR 200
Description: Wang Resin

Wang Resin

A6776-25000 25 g
EUR 125
Description: Wang Resin

Aminomethyl Polystyrene Resin

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Aminomethyl Polystyrene Resin

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Aminomethyl Polystyrene Resin

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Aminomethyl Polystyrene Resin

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Glutathione Agarose Resin

4B-GLU-10 10 ml
EUR 173

Glutathione Agarose Resin

4B-GLU-100 100 ml
EUR 996

Biotin Agarose Resin

4BCL-BI-10 10 ml
EUR 411

Biotin Agarose Resin

4BCL-BI-5 5 ml
EUR 235

Ni-NTA Resin

20-abx098108
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Ni-IDA Resin

20-abx098109
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  • EUR 230.00
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  • 5 ml
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Protein A Resin

abx098111-5ml 5 ml
EUR 398
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Protein G Resin

abx098112-5ml 5 ml
EUR 439
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MP-EDC resin

20-abx095129
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  • EUR 439.00
  • EUR 217.00
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MP-TEMPO resin

20-abx095130
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  • EUR 439.00
  • EUR 217.00
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MP-Aminomethyl resin

20-abx095132
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  • EUR 189.00
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MP-Acetylacetone resin

20-abx095133
  • EUR 439.00
  • EUR 230.00
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MP-Piperazinomethyl resin

20-abx095134
  • EUR 439.00
  • EUR 230.00
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  • 25 g
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MP-Diethylenetriamine resin

20-abx095136
  • EUR 453.00
  • EUR 230.00
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MP-Carbonate resin

20-abx095138
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  • EUR 244.00
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MP-Morpholinomethyl resin

20-abx095139
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MP-Thiosulfate resin

20-abx095140
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MP-Mercaptomethyl resin

abx095141-100g 100 g
EUR 509
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MP-TMT resin

20-abx095142
  • EUR 578.00
  • EUR 272.00
  • 100 g
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Rink Amide Resin

A6576-100000 100 g
EUR 947
Description: Rink resin is originally developed for SPS of peptide amides. Now the scope of its application is extended from carboxylic amides to the immobilization of amines, substituted amides.

Rink Amide Resin

A6576-25000 25 g
EUR 299
Description: Rink resin is originally developed for SPS of peptide amides. Now the scope of its application is extended from carboxylic amides to the immobilization of amines, substituted amides.

DHP HM Resin

A6789-100000 100 g
EUR 514
Description: DHP HM Resin

DHP HM Resin

A6789-25000 25 g
EUR 203
Description: DHP HM Resin

GST-Sefinose Resin

BSP031 5ml
EUR 145.7
  • Product category: Biochemicals/Biology Reagents/Protein Related

GST-Sefinose Resin

BSP031-1 25ml
EUR 415.4
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Nickel NTA Agarose Resin

6BCL-NTANi-100 100 ml
EUR 651

Nickel NTA Agarose Resin

6BCL-NTANi-25 25 ml
EUR 217

Nickel NTA Agarose Resin

6BCL-NTANi-500 500 ml
EUR 2584

Fmoc-Ala-Wang resin

5-07835 5g Ask for price

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Fmoc-Cit-Wang resin

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Fmoc-Gly-Wang resin

5-07891 5g Ask for price

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Fmoc-Ile-Wang resin

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Fmoc-Leu-Wang resin

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Fmoc-Met-Wang resin

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Fmoc-Phe-Wang resin

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Fmoc-Phe-Wang resin

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Fmoc-Phe-Wang resin

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Fmoc-Phe-Wang resin

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Fmoc-Pro-Wang resin

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Fmoc-Tle-Wang Resin

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Fmoc-Thr-Wang resin

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Fmoc-Thr-Wang resin

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Fmoc-Val-Wang resin

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Fmoc-Val-Wang resin

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2-Chlorotrityl Chloride Resin

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2-Chlorotrityl Chloride Resin

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2-Chlorotrityl Chloride Resin

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Fmoc-Leu-Tcp Resin

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Fmoc-Leu-Tcp Resin

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Protein A-Agarose Resin

55000 1 mL
EUR 132
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200

Protein A-Agarose Resin

55005 5 mL
EUR 306
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200

Protein L Agarose Resin

4BCLPL-10 10 ml
EUR 393

Protein L Agarose Resin

4BCLPL-2 2 ml
EUR 197

Protein L Agarose Resin

4BCLPL-5 5 ml
EUR 284

Fmoc-Gly-Wang resin

20-abx095122
  • EUR 551.00
  • EUR 258.00
  • 100 g
  • 25 g
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MP-Sulfonic acid resin

20-abx095135
  • EUR 439.00
  • EUR 230.00
  • 100 g
  • 25 g
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2-Chlorotrityl Chloride resin

20-abx095137
  • EUR 467.00
  • EUR 899.00
  • EUR 230.00
  • EUR 1609.00
  • 100 g
  • 250 g
  • 25 g
  • 500 g
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Rink Amide AM resin

20-abx095146
  • EUR 801.00
  • EUR 4156.00
  • EUR 1455.00
  • EUR 328.00
  • EUR 2249.00
  • 100 g
  • 1 kg
  • 250 g
  • 25 g
  • 500 g
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Rink Amide-AM Resin

A6780-100000 100 g
EUR 727
Description: Rink Amide-AM Resin

Rink Amide-AM Resin

A6780-25000 25 g
EUR 389
Description: Rink Amide-AM Resin

Rink Amide-AM Resin

A6780-5000 5 g
EUR 219
Description: Rink Amide-AM Resin

2-Chlorotrityl Chloride Resin

A6791-100000 100 g
EUR 328
Description: 2-Chlorotrityl Chloride Resin

2-Chlorotrityl Chloride Resin

A6791-25000 25 g
EUR 142
Description: 2-Chlorotrityl Chloride Resin

Fmoc-Phe-Wang resin

A6831-25000 25 g
EUR 205
Description: Fmoc-Phe-Wang resin

Fmoc-Phe-Wang resin

A6831-5000 5 g
EUR 87
Description: Fmoc-Phe-Wang resin

Fmoc-Ile-Wang resin

A6836-25000 25 g
EUR 205
Description: Fmoc-Ile-Wang resin

Fmoc-Ile-Wang resin

A6836-5000 5 g
EUR 87
Description: Fmoc-Ile-Wang resin

Fmoc-Gly-Wang resin

A6839-25000 25 g
EUR 205
Description: Fmoc-Gly-Wang resin

Fmoc-Gly-Wang resin

A6839-5000 5 g
EUR 87
Description: Fmoc-Gly-Wang resin

Protein A Agarose Resin

PA09-100 100 ml
EUR 2094

Protein A Agarose Resin

PA09-25 25 ml
EUR 925

Protein A Agarose Resin

PA09-5 5 ml
EUR 291

Streptavidin 6HC Agarose Resin

STV6HC-10 10 ml
EUR 399

Streptavidin 6HC Agarose Resin

STV6HC-20 20 ml
EUR 685

Streptavidin 6HC Agarose Resin

STV6HC-5 5 ml
EUR 237

Protein A Agarose Resin

BSP095-7 1ml
EUR 93.5
  • Product category: Biochemicals/Biology Reagents/Protein Related

Protein A Agarose Resin

BSP095-8 5ml
EUR 245.75
  • Product category: Biochemicals/Biology Reagents/Protein Related

Protein A Sefinose Resin

BSP096-25 12.5ml
EUR 702.5
  • Product category: Biochemicals/Biology Reagents/Protein Related

Protein A Sefinose Resin

BSP096-5 2.5ml
EUR 193.55
  • Product category: Biochemicals/Biology Reagents/Protein Related

Protein G Agarose Resin

SF022-PG 5ml
EUR 775
  • Product category: Biochemicals/Biology Reagents/Protein Related

Fmoc-1-Nal-Wang resin

5-07831 5g Ask for price

Fmoc-1-Nal-Wang resin

5-07832 25g Ask for price

Fmoc-2-Nal-Wang resin

5-07833 5g Ask for price

Fmoc-2-Nal-Wang resin

5-07834 25g Ask for price

Fmoc-D-Ala-Wang resin

5-07837 5g Ask for price

Fmoc-D-Ala-Wang resin

5-07838 25g Ask for price

Fmoc-Arg(Pbf)-Wang resin

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Fmoc-Arg(Pbf)-Wang resin

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Fmoc-Asn(Trt)-Wang resin

5-07847 5g Ask for price

Fmoc-Asn(Trt)-Wang resin

5-07848 25g Ask for price

Fmoc-Asp(OtBu)-Wang resin

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Fmoc-Asp(OtBu)-Wang resin

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Fmoc-Asp-OAll-Wang Resin

5-07855 5g Ask for price

Fmoc-Asp-OAll-Wang Resin

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Fmoc-Cys(Acm)-Wang resin

5-07869 5g Ask for price

Fmoc-Cys(Acm)-Wang resin

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Fmoc-Cys(Trt)-Wang resin

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Fmoc-Cys(Trt)-Wang resin

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Fmoc-Cys(Trt)-Wang resin

5-07873 5g Ask for price

Fmoc-Cys(Trt)-Wang resin

5-07874 25g Ask for price

Fmoc-Gln(Trt)-Wang resin

5-07879 5g Ask for price

Fmoc-Gln(Trt)-Wang resin

5-07880 25g Ask for price

Fmoc-Glu(OAll)-Wang resin

5-07883 5g Ask for price

Following the multitude of food microbe combinations, there are thousands of different types of fermented dairy products – yogurts, yogurt type products and various types of cheeses with proven health benefits. Among these products is the domestic Bulgarian yoghurt “Kiselo Mlyako”, whose anti-aging effect has been scientifically studied at the beginning of the 20th century. The current review overwrites the wide range of traditional fermented dairy products in the Balkan countries, which are the main source of their production.

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